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组蛋白去乙酰化酶在心血管系统中的研究进展

The overview and potential effect of histone deacetylase in cardiovascular disease
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摘要 组蛋白去乙酰化酶（HDAC）是细胞核内催化组蛋白去乙酰化的一类蛋白酶，参与染色体结构修饰和基因的表达调控。已被证实，HDAC参与部分心血管疾病的发生与发展，在心血管系统中具有重要作用。本文将对HDAC在心血管系统中的研究进展做一综述，旨在为心血管疾病的临床治疗提供参考。 Histone deacetylase （HDAC） catalyze the removal of acety - groups from lysine residues of nuclear histone, modify the structure of chromosome, as well as regulate gene expression. It has been confirmed that HDAC, which plays a significant role in cardiovascular system, is involved in cardiovascular diseases. This article compiled here will be give an overview of HDAC in cardiovascular system, aiming to serve as a comprehensive reference for the research progress and clinical treatment of the cardiovascular diseases.
作者 宋福军 关世奎 李天 闫小龙 蒋帅 杨阳
机构地区 北京军区北戴河疗养院普通外科 北京军区北戴河疗养院院务部 第四军医大学生物医学工程系
出处 《中华实验外科杂志》 CAS CSCD 北大核心 2016年第1期275-277,共3页 Chinese Journal of Experimental Surgery
基金 国家自然科学基金（81500263） 国家博士后基金（2015M572681） 第四军医大学博士学位资助课题（20131301）
关键词 组蛋白去乙酰化酶 乙酰化 心血管系统 Histone deacetylase Acetylation Cardiovascular system
分类号 R730.2 [医药卫生—肿瘤]
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中华实验外科杂志
2016年 第1期

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