一株深海真菌FS86的分离鉴定及其生物活性研究

Isolation and Identification of a Deep-sea-derived Fungus FS86 and Its Biological Activities

采用平板涂布法从南海深海沉积物中分离出一株真菌FS86,根据培养特征、形态学特征和ITS序列分析,该菌株被鉴定为球孢枝孢(Cladosporium sphaerospermum)。生物活性测试结果表明,其发酵提取物对8种病原真菌和4种肿瘤细胞株都具有明显的抑制作用,其MIC值和IC50值分别为0.1-4 mg/m L和0.86-2.13μg/m L。

A strain of fungus FS86 was isolated from deep-sea sediment of South China Sea by the spread plate method. According to the culture features, morphological characteristics and ITS sequence analysis, the strain was identified as Cladosporium sphaerospermum. Bioassay results showed that the fermentation extract of the strain FS86 demonstrated significant inhibitory effects against 8 pathogenic fungi and 4 tumor cell lines with MICs of 0.1-4 mg/m L and IC50 values of 0.86-2.13 μg/m L, respectively.