喉癌患者采用喉部分切除术的近、远期疗效分析

Short-term and long-term curative effect of partial laryngectomy for laryngeal cancer

目的：分析喉癌患者采用喉部分切除术的近、远期疗效，并与喉全切除术进行比较。方法：纳入统计2010年1月～2014年1月，河南省平顶山市第二人民医院收治的接受外科手术治疗的喉癌患者94例的医疗资料。按照手术方式的不同将研究对象分为观察组（喉部分切除术）49例及对照组（喉全切除术）45例。结果：观察组患者治疗后1周血清IL-6水平显著低于对照组（P〈0．001）；CRP水平亦显著低于对照组（P=0．001）。术后，观察组吞咽功能评估优良率（73．5％）高于对照组（40．0％），两者比较差异具有统计学意义（P=0．001）。生存曲线分析显示观察组患者术后5年（60个月）生存率与对照组相比差异无统计学意义（P〉0．05）。结论：在喉癌的治疗中，采用喉部分切除术可达到与喉全切除术相当的远期疗效，且更大程度保护了患者的吞咽功能。

Objective： To analyze the evaluation the short-term and long-term curative effect of partial laryngectomy for laryngeal cancer. Methods： Clinical data of patients with laryngeal cancer received treatment at our hospital from 2010 to 2014 was analyzed. Patients were divided into two groups by therapeutic methods： Group A, partial laryngectomy： group B, total laryngectomy. Results.. A total of 94 patients were analyzed （Group A 49 cases, Group B 45 cases）. Levels of CRP and IL-6 in Group A were significantly lower than these of Group B （P〈0. 001）. Group A had higher excellent rate of swallowing function than that of Group B （73.5 %, 36/49 vs 40.0%, 18/45, χ2 = 10. 750, P= 0. 001）. Kaplan-Meier analysis showed that Group A had similar 5 years survival rate compared to that of Group B （75.7%, 37/49 vs 77.8%, 35/45; Log-rankχ 2=0. 063, P=0. 801）. Oonclusion： Part throat resection has the similar long-term curative effect to total resection, and patients＇ swallowing function can be protected.