大珠红景天对高原急性脑梗死患者血清超氧化物岐化酶、丙二醛等指标水平的影响

Effect ofrhodiola on serum SOD,MDA,OX-LDL and MMP-2 levels in patients with acute cerebral infarctionin plateau areas

目的通过检测高原地区急性脑梗死患者血清超氧化物岐化酶(SOD)、丙二醛(malondialdehyde,MDA)、氧化低密度脂蛋白(oxidized low density lipoprotein,OX-LDL)和基质金属蛋白酶-2(matrixmetalloproteinases-2,MMPS-2)的表达水平,探讨大珠红景天治疗高原急性脑梗死的可能机制。方法将60例高原地区急性脑梗死患者随机分为试验组(n=30)和对照组(n=30)。试验组给予大株红景天注射液10 ml入250 ml 5%葡萄糖溶液中,每日1次静脉滴注,疗程为10 d,对照组给予常规治疗,不滴注红景天注射液。分别检测2组治疗前及治疗后第10天的血清SOD、MDA、MMP-2和OX-LDL的含量变化。结果治疗后,与对照组比较,试验组血清SOD[(97.19±8.68)vs.(89.90±9.48)Nu/ml]的含量明显升高,MDA[(6.88±1.95)vs.(8.36±2.98)nmol/ml]、OX-LDL[(29.20±8.99)vs.(38.19±8.55)μg/dl]和MMP-2[(20.00±8.04)vs.(25.70±8.24)μg/dl]的含量明显降低,差异具有统计学意义(P<0.05)。结论大珠红景天可能通过上调血清SOD的表达,同时下调MDA、OXLDL和MMP-2的表达,从抗氧化和抑制动脉粥样硬化方面发挥治疗高原急性脑梗死的作用。

Objective To investigate the clinical curative effect of rhodiola glucoside in patients with acute cerebral infarction in plateau areas. Methods Sixty cases of acute cerebral infarction from plateau areas were randomly divided into two groups trial group（ n = 30） and control group（ n = 30 ）. The patients in the trial group were given conventional treatment and big bead rhodiola injection ,while the patients in the control group were given conventional treatment. The serum levels of Superoxide dismutase （ SOD）, malondialdehyde （ MDA ）, oxidized low density lipoprotein （OX-LDL） and matrix metalloproteinase-2（MMP-2） were detected before the treatment and 10 days after the treatment. Results After the treatment, as compared with the control group, the level of SOD increased obviously [ （ 97.19 ± 8.68 ） vs. （ 89.90 ± 9.48） Nu/ml] in the trial group ; but the levels of MDA [ （ 6.88 ± 1.95 ） vs. （ 8.36 ± 2.98 ） nmol/ml ], OX-LDL [ （29.20 ± 8.99） vs. （38.19 ± 8.55 ） μg/dl ] and MMP-2 [ （20.00 ± 8.04） vs. （ 25.70 ± 8.24） μg/dl ] decreased significantly,the difference between the two groups was statistical significant （P 〈 0.05 ）. Conclusion The rhodiola injection is effective for patients with acute cerebral infarction in plateau areas throughupregulating the expression of SOD and downregulating the expression of MDA, OX-LDL and MMP-2,thereby improve the antioxidant and inhibit atherosclerosis.