温针灸对糖尿病胃轻瘫患者胃肠激素的影响

Effect of warming needle moxibustion on gastrointestinal hormone of diabetic gastroparesis patients

目的目前运用针灸疗法治疗糖尿病胃轻瘫的报道甚多,但多数报道只是临床疗效的总结,而对针灸治疗该病的机制探讨尚少,缺乏治疗结果的可重复性和说服力。本研究通过探讨温针灸对糖尿病胃轻瘫患者胃肠激素的影响并评价其疗效,为温针灸治疗糖尿病胃轻瘫的治疗机制提供思路。方法将100例患者随机分为2组,治疗组50例给予温针灸治疗,1次/d,5次1个疗程,每治疗完一个疗程休息2 d;对照组50例予西药多潘立酮10mg治疗,饭前30 min口服,3次/d,2组均治疗4周,观察临床疗效、治疗前后胃肠激素的变化、小钡条在胃内残留情况。结果对照组总有效率为78.00%,治疗组总有效率为98.00%,差异具有统计学意义(P<0.05)。2组治疗后总体症状积分、小钡条在胃内残留情况、胃肠激素水平与同组治疗前比较,差异均有统计学意义(P<0.05)。治疗组治疗后总体症状积分、小钡条在胃内残留情况、胃肠激素水平与对照组比较,差异均有统计学意义(t值分别为11.02、13.23、16.27、15.81,P<0.05)。结论温针灸是一种治疗糖尿病胃轻瘫的有效方法,改善胃动力效果显著,其作用机制可能是降低患者胃肠激素水平,为探讨温针灸治疗糖尿病胃轻瘫的治疗机制提供了思路。

Objective At present many reports use acupuncture for treatment of diabetic gastroparesis , but most reports only summarize the clinical efficacy, and explore the mechanism of acupuncture for the treatment of the disease is still small, lack of treatment results and persuasive repeat ability. This study evaluated the efficacy and provide ideas for warm acupuncture therapy of diabetic gastroparesis by acupuncture study the effect of temperature on patients with diabetic gastroparesis gastrointestinal hormones. Methods One hundred patients were randomly divided into two groups. In treatment group,50 patients were given warm acupuncture treatment, 1 day,5 times a course of treatment, complete a course of treatment every two days of rest;in the control group,50 cases were treated with domperidone 10 mg treatment, orally 30 min before meals, three times a day,the two groups were treated for 4 weeks, clinical efficacy, changes in gastrointestinal hormones before and after treatment, a small strip in the stomach residual barium situation. Results The total effective rate was 78.00% in the control group,total effective rate was 98.00% in treatment group,has a statistically significant （ P 〈 0.05 ）. Group 2 overall symptom score after treatment, a small residual barium strip in front of the stomach, the gastrointestinal hormone therapy with the same group, the difference was statistically significant （ P 〈 0.05 ）. After treatment, the overall symptom score, a small residual barium strip in the stomach, the gastrointestinal hormone levels compared with control group, the differences were statistically significant （ t values were 11.02,13.23,16.27,15.81, P 〈 0.05 ）. Conclusion Warm Acupuncture is an effective method for treatment of diabetic gastroparesis, improve gastric motility significant effect,its mechanism may be decreasing gastrointestinal hormone levels of patients. Acupuncture provides a guidehne for the warm treatment of diabetic gastroparesis treatment mechanism.