Non-alkaloid constituents of Vinca major

The present study was designed to investigate the non-alkaloid compounds from the leaves and stems of Vinca major cultivated in Yunnan Province, China. The compounds were isolated using chromatographic techniques. The structures were elucidated by 1D- and 2D-NMR spectroscopic methods in combination with UV, IR, and MS analyses. The 1, 1-diphenyl-2-picrylhydrazyl （DPPH）-scavenging activity of Compounds 1-7 were evaluated. One new iridoid glycoside （compound 1）, together with 11 known compounds, were isolated from Vinca major. Compounds 1, 5, and 6 showed moderate DPPH-scavenging activity, with IC50 values being 70.6, 32.8, and 62.2μmaol·L 1, respectively. In conclusion, compound 1 is a newly identified iridoid glycoside with moderate antioxidant activity.

The present study was designed to investigate the non-alkaloid compounds from the leaves and stems of Vinca major cultivated in Yunnan Province,China.The compounds were isolated using chromatographic techniques.The structures were elucidated by 1D-and 2D-NMR spectroscopic methods in combination with UV,IR,and MS analyses.The 1,1-diphenyl-2-picrylhydrazyl(DPPH)-scavenging activity of Compounds 1–7 were evaluated.One new iridoid glycoside(compound 1),together with 11 known compounds,were isolated from Vinca major.Compounds 1,5,and 6 showed moderate DPPH-scavenging activity,with IC_(50) values being 70.6,32.8,and 62.2 μmol·L^(-1),respectively.In conclusion,compound 1 is a newly identified iridoid glycoside with moderate antioxidant activity.