坏死性凋亡的信号转导机制及其在神经外科疾病中的研究进展

Signal transduction mechanisms of necroptosis and relevant advances in neurosurgical diseases research

坏死性凋亡是指一种以凋亡形式开始的、有坏死表型并被称为程序性坏死或肿瘤坏死因子(TNF)诱导性坏死的一种新的细胞死亡模式。程序性坏死在一些神经外科疾病所引起的神经细胞损伤及死亡中扮演着重要角色,其中包括颅脑外伤、颅内肿瘤和脑血管疾病等。坏死性凋亡信号转导机制的逐渐明晰及高效特异性抑制剂(如necrostatin-1)的发现,为神经外科相关疾病的临床治疗提供新的思路。该文就坏死性凋亡的发现和机制进展进行综述。

Necroptosis is a new mode of cell death that starts with the form of apoptosis, performs as the necrosis-like phenotype, and is known as programmed necrosis or tumor necrosis factor-induced （TNF-induced） necrosis. The programmed necrosis plays an important role in the injury and death of neuronal cell due to some neurosurgical diseases, including craniocerebral trauma, brain tumor, and cerebrovascular diseases. The gradual understanding of signal transduction mechanisms of necroptosis and the discovery of potent specific inhibitors （such as necrostatin-1） provide new ideas for the clinical treatment of neurosurgical diseases. This paper reviews the advances in discovery and mechanisms of necroptosis.