肺内皮多糖包被与急性肺损伤的研究进展

Research progress on pulmonary endothelial gycocalyx and acute lung injury

内皮多糖包被(endothelial glycocalyx,EG)位于血管内皮细胞腔面,由蛋白聚糖(proteoglycan,PG)、糖胺聚糖(glycosaminoglycan,GAG)、膜糖蛋白及血浆蛋白组成。肺血管内皮的多糖包被可阻止中性粒细胞黏附和外渗,并影响内皮通透性的活性调控。多糖包被在急性肺损伤(acute lung injury,ALI)的发生、发展过程中可能起着重要的作用。对多糖包被的保护或重构可能是急性肺损伤临床治疗的一个新思路。

Located on the luminal surface of vascular endothelial cells, the endothelial glycocalyx is composed of proteoglycan, glycosaminoglycan, glycoproteins and a wide array of molecules from plasma. Pulmonary endothelial glycocalyx serves as a barrier to neutrophil adhersion and extravasation. And it also has an impact on the active regulation of endothelial permeability. Endothelial glycocalyx plays a pivotal role in acute lung injury. Protection or reconstruction of glycocalyx may prove to be a new therapeutic approach for acute lung injury.