大鼠全脑缺血再灌注损伤后SnoN mRNA的表达
摘要
在中枢神经系统中轴突的生长为神经元之间的连接奠定了最根本的作用,目前研究发现中枢神经系统损伤后轴突是可以再生的,但是再生能力是有限的。近年来研究发现细胞周期后期分裂促进复合物（anaphase promoting complex,APC）与其调节亚基Cdh1在哺乳动物大脑皮质、海马、小脑等部位的终分化神经元的核内有大量的表达,且具有抑制神经元轴突生长及发育的作用[1];
出处
《山西医药杂志》
CAS
2016年第1期25-27,共3页
Shanxi Medical Journal
参考文献8
-
1Gieffers C,Peters BH,Kramer ER,et al.Expression of the CDHl-associated form of the anaphase-promoting complex in postmitotic neurons[J].Proc Natl Acad Sci USA,1999,96(20):11317-11322.
-
2Stegmuller J,Konishi Y,Huynh MA,et al.Cell-intrinsic regulation of axonal morphogenesis by the Cdhl-APC target SnoN[J].Neuron,2006,50(3):389-400.
-
3Huynh MA,Ikeuchi Y,Netherton S,et al.An isoform-spe- cific SnoNl-FOXOl repressor complex controls neuronal mor- phogenesis and positioning in the mammalian brain[J].Neu- ron,2011,69(5):930-944.
-
4Nunn JA,Gray JA,Hodges H.Neurotoxic dorsal CA1 le- sions versus 4 VO ischaemic lesions:behavioural comparisons[J].Behav Neurol,1998,11(4):217-226.
-
5Schmittgen TD,Livak KJ.Analyzing real-time PCR data by the comparative C(T)method[J].Methods,2008,3(6):1101-1108.
-
6Stegmiiller J,Huynh MA,Yuan Z,et al.TGFbeta-Smad2 signaling regulates the Cdhl-APC/SnoN pathway of axonal morphogenesis[J].J Neurosci,2008,28(8):1961-1969.
-
7姚文龙,张传汉,钱巍,邱瑾,柳璐,祝畅,桂伶俐.APC-Cdh1在中枢神经系统中的表达分布特点[J].第四军医大学学报,2009,30(13):1161-1164. 被引量：4
-
8Huynh MA,Stegmuller J,Litterman N,et al.Regulation of Cdhl-APC functions in axon growth by Cdhl phosphorylation[J].J Neurosci,2009,29(13):4322-4327.
二级参考文献10
-
1Kim AH,Bonni A.Thinking within the D box:Initial identification of Cdh1-APC substrates in the nervous system[].Mol Cell Neuro sci.2007
-
2Bahrami AR,Matin MM,Andrews PW.The CDK inhibitor p27en-hances neural differentiation in pluripotent NTERA2human EC cells,but does not permit differentiation of2102Ep nullipotent hu-man EC cells[].Mechanisms of Development.2005
-
3Peters J M.The anaphase-promoting complex: proteolysis in mitosis and beyond[].Molecular Cell.2002
-
4Livak KJ,Schmittgen TD.method[].Methods.2001
-
5Yoshikawa K.Cell cycle regulators in neural stem cells and postmitotic neurons[].Neurosciences Research.2000
-
6Wei W,Ayad N G,Wan Y,et al.Degradation of the SCF component Skp2 in cell-cycle phase G1 by the anaphase-promoting complex[].Nature.2004
-
7Cernak,I,Stoica,B,Byrnes,KR.Role of the cell cycle in the pathobiology of central nervous system trauma[].Cell Cycle.2005
-
8Rashidian J,Iyirhiaro GO,Park DS.Cell cycle machinery and stroke[].Biochimica et Biophysica Acta.2007
-
9Yoshiyuki Konishi,Judith Stegmü,ller,Takahiko Matsuda,Shirin Bonni,Azad Bonni.Cdh1-APC Controls Axonal Growth and Patterning in the Mammalian Brain[].Science.2004
-
10Visintin R,Prinz S,Amon A.Cdc20 and Cdh1: a family of substrate-specific activators of APC-dependent proteolysis[].Science.1997
共引文献3
-
1钱巍,邱瑾,祁月红,姚文龙,张雪,张传汉.大鼠局灶性脑缺血后Cdh1 mRNA水平及Cdh1蛋白分布的改变[J].神经损伤与功能重建,2010,5(6):399-403.
-
2孟巍,邢艳丽,刘帅.减重步行训练结合针刺治疗对脊髓损伤大鼠运动功能及Cdh1 mRNA表达的影响[J].中国康复医学杂志,2012,27(7):635-638. 被引量：5
-
3李立,石小云,张登文,张传汉,姚文龙.突变型Cdh1基因真核表达质粒的构建及鉴定[J].中国组织工程研究,2013,17(2):315-319.
-
1钱巍,邱瑾,祁月红,姚文龙,张雪,张传汉.大鼠局灶性脑缺血后Cdh1 mRNA水平及Cdh1蛋白分布的改变[J].神经损伤与功能重建,2010,5(6):399-403.
-
2陈志则,万里,张传汉,祁月红,张雪,姚文龙,邱谨.大鼠全脑缺血再灌注损伤后APC-Cdh1mRNA的表达变化[J].中风与神经疾病杂志,2010,27(5):426-428.
-
3陈志则,万里,祁月红,姚文龙,邱瑾,张传汉.大鼠全脑缺血-再灌注损伤后APC-Cdh1蛋白的表达[J].中国康复理论与实践,2010,16(4):339-341. 被引量：1
-
4邱瑾,钱巍,张传汉.细胞周期末期促进复合物及其调节亚基Cdh1在缺血性脑损伤中的作用[J].国际麻醉学与复苏杂志,2009,30(4):360-363. 被引量：1
-
5祁月红,钱巍,李平,姚文龙,邱瑾,张传汉.大鼠脊髓部分横切损伤后APC-Cdh1在损伤脊髓组织中的表达[J].中国神经免疫学和神经病学杂志,2009,16(4):285-288. 被引量：1
-
6陈志则,祁月红,张雪,姚文龙,张传汉.慢病毒介导的Cdh1-siRNA在大鼠全脑缺血再灌注损伤后的表达及功能[J].中国康复,2013,28(3):163-166.
-
7张洁,欧阳文.异氟醚对老年大鼠脑组织神经元凋亡的影响[J].中华麻醉学杂志,2009,29(7):610-612. 被引量：2
-
8邱瑾,姚文龙,张玥,邹姮婧,石小云,李大佳,张传汉.慢病毒过表达Cdh1蛋白对星形胶质细胞反应性增殖作用的初步研究[J].中风与神经疾病杂志,2012,29(2):100-102. 被引量：2
-
9刘鹏斌,常丹,宋正川,丁晓英,张珍妮.氯胺酮麻醉对大鼠局灶性脑缺血模型病理结局的影响(英文)[J].中国临床康复,2006,10(34):187-189. 被引量：2
-
10鲁向锋,邱洪斌,汪志国,王斌有.脂多糖致胎鼠脑白质损伤探讨[J].黑龙江医药科学,2004,27(3):14-15. 被引量：1
