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谷氨酸转运体3在神经功能调节中的作用研究进展 被引量：3

The Research Progress of EAAT3 in Neural Functional Regulation
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摘要 谷氨酸是哺乳动物中枢神经系统内一种主要的兴奋性神经递质,当神经元突触间隙出现大量兴奋性氨基酸堆积时,就可造成神经毒性作用甚至细胞死亡,进而出现认知功能改变及其他的精神神经疾病。引起兴奋性氨基酸堆积的原因很多,其中兴奋性氨基酸转运体(EAAT)的改变与其密切相关,而EAAT3是谷氨酸转运体之一,它对突触间谷氨酸浓度的调控、谷胱甘肽(中枢神经系统的抗氧化剂)的合成具有重要意义。另外,EAAT3本身与神经保护以及认知功能也密切相关。 Glutamate is a primary excitatory neurotransmitter of the central nervous system （CNS） in mammals. When a lot of excitatory amino acid accumulate in synaptic cleft, it will produce neurotoxic effect or even cell death, which may further cause cognitive dysfunction and other neuropsychiatric disorder. There are many reasons to induce excitatory amino acid accumulation, and the change of excitatory amino acid trans- porters（EAAT） is one of the reasons, and EAAT3 is one of the glutamate transporters, which plays an impor- tant role in regulating glutamate concentration between synapsis and the synthesis of glutathione（ antioxidant of CNS）. Besides, EAAT3 itself is closely associated with nerve protection and cognitive function as well.
作者 王沛齐 刘娜 周恩禄 曹江北 张宏
机构地区 解放军总医院麻醉手术中心 河北省承德医学院附属医院麻醉科 解放军
出处 《医学综述》 2016年第2期238-241,共4页 Medical Recapitulate
基金 国家自然科学基金(81541114) 总后勤部保健专项课题(13BJZ38)
关键词 兴奋性氨基酸转运体3 谷氨酸 生理学 谷胱甘肽 病理学 Excitatory amino acid transporters 3 Glutamate Physiology Glutathione Pathology
分类号 R614.2 [医药卫生—麻醉学]
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参考文献42

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二级参考文献98

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医学综述
2016年 第2期

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