抗菌药物优化给药方案研究进展

Research Progress in Optimized Regimens of Antibacterial Agents

抗菌药物通过优化应用获得最强的抗菌活性、最佳的临床效果、减少毒性以及预防耐药性的给药方案。药动学/药效学参数与临床疗效密切相关,并从其角度考虑各种情况下包括病理生理状态下剂量选择,从药物毒性角度确定用药方案。重视普通敏感菌感染、耐药菌感染或严重感染患者不同剂量和方案的选择,重症患者重视负荷剂量。优化给药方案尚是不断探索、实践、完善的过程,基于耐药机制、联用的具体方案、群体药代动力学模型等研究是新趋势。

Through optimization of the application, the strongest antibacterial activity, best clinical efficacy, drug toxicity reduction and to drug resistance prevention can be achieved. The parameters of pharmacokinetics/pharmacodynamics are closely related to the clinical effect, and the choice of dosage should be considered from its point of view under various conditions including physiological and pathological condition, and the medication regimens should be determined from drug toxicity. The selection of different doses and regimens for patients with ordinary bacterial infection, resistant bacteria infection, or severe infection should be paid due attention, and loading dose should be considered in critically ill patients. Optimization of the prescription is still in the process of exploring, practicing and improving, and the specific programs based on the mechanism of drug resistance and combination, and the population pharmacokinetic model, are the new trend in th, field.