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血清NT-proBNP水平与慢性心力衰竭患者再住院率及生存率的关系 被引量:14

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摘要 目的探讨血清N-端脑利钠肽前体(NT-proBNP)水平与慢性心力衰竭(CHF)患者再住院率及生存率的关系及临床意义。方法选择2012年1月至2013年12月CHF患者196例。所有患者均常规予以药物治疗,对比患者治疗前后的心功能分级和对应的血清NT-proBNP水平。随访1年,比较不同血清NT-proBNP水平患者的再住院率与生存率,并分析二者之间的相关性。结果患者治疗前后随着心功能分级增加,血清NTproBNP水平均显著上升,心功能分级与血清NT-proBNP水平呈正相关(P〈0.05)。治疗后各心功能分级患者的血清NT-proBNP水平均显著低于治疗前(均P〈0.05)。血清NT-proBNP水平为2 000~4 999 pg/ml时患者的再住院率显著低于5 000~9 000 pg/ml及≥9 001 pg/ml的患者,但生存率显著高于5 000~9 000 pg/ml及≥9 001 pg/ml的患者(均P〈0.05)。血清NT-proBNP水平与再住院率呈正相关,与生存率呈负相关。结论血清NT-proBNP水平与CHF患者再住院率存在正相关联系,与生存率存在负相关联系,对其进行监测对于CHF患者的预后评估具有重要的临床意义。
作者 吴和弟
出处 《中国老年学杂志》 CAS CSCD 北大核心 2016年第2期338-339,共2页 Chinese Journal of Gerontology
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