炎症小体与中枢神经系统疾病

Inflammasome and diseases of central nervous system

炎症小体是一蛋白复合物,能够识别不同刺激信号,活化后能诱导免疫和炎症应答。NLRP3炎症小体是中枢神经系统中研究最广泛的炎症小体。小胶质细胞、血管周围的巨噬细胞和脑膜巨噬细胞均能表达炎症小体,而炎症小体与急性脑部感染、急性无菌性脑损伤、帕金森病和阿尔茨海默病等的发生发展有密切关系。基于炎症小体与中枢神经系统疾病相关的机制探索和靶向药物开发是目前的研究热点。

Inflammasome is the body of protein complex which is able to identify different stimulation signals and can in- duce immune and inflammatory responses when it is activated. NLRP3 inflammasome has been extensively studied in the central nervous system. Microglia, perivaseular macrophages and meningeal macrophages express inflammasomes. The occurrence and development of acute brain infection, aseptic acute brain injury, Parkinson disease and Alzheimer disease are closely related to inflammasomes. Based on mechanisms exploration of the inflammasome＇s role in the central nervous system disorders, its tar get drug research and development will be greatly addressed in the future.