不同剂型五苓散对磺胺氯丙嗪钠解毒功效的研究

Research of Different Formulations of Wuling Powder on the Detoxification Effects of Sulfachloropyrazine Sodium

为探究不同剂型的五苓散对磺胺氯丙嗪钠引起肾中毒的解毒功效,分别用五苓散的散剂、煎剂和可溶性粉对磺胺氯丙嗪钠中毒的小鼠进行治疗。通过观察其泌尿系统器官的组织学形态变化,以及测定治疗前后的小白鼠血清中尿素氮和肌酐的含量。结果表明:三种剂型的五苓散饲喂肾中毒小鼠3 d后,组织形态观察小鼠的肾小管上皮、输尿管、膀胱黏膜、尿道肌层等泌尿系统的组织病变均消失;血清中尿素氮和肌酐含量显著下降(P<0.05),并且各剂型间无显著差异,结果提示在生产中五苓散剂型的选择可依不同动物的用药习惯而定。

To explore different formulations of Wuling powder on detoxification effects of nephrotoxieity induced by sulfachloropyrazine sodium. The mice were injected with sulfachloropyrazine sodium for establishing the renal poisoning model. Then they were treated with different formulations of Wuling powder： pulvis, extracts and soluble powder. After treatment, the histological characteristics of the urinary system were observed, urea nitrogen and creatinine levels in the serum of mice were determined. The results showed that three formulations of Wuling powder fed renal poisoning mice after 3 d, the pathological changes of renal tubular epithelial, ureter, bladder mucosa and urethra muscular tissue were disappearing. The urea nitrogen and creatinine levels in serum decreased significantly （P 〈 0.05 ）, and no significant difference among different formulations. Therefore Wuling powder can restore the urinary tract tissue pathological changes caused by sulfanilamide chlorpromazine sodium. In practice, the choice of appropriate formulation of Wuling powder depends on different prescribing habits of animals.