TRPV4通道蛋白在肿瘤发生发展中的研究进展

TRPV4 in occurrence and development of cancer: recent progress

TRPV4通道是瞬时受体电位通道家族(TRP)的成员,属非选择性阳离子通道,可被热、机械力、佛波醇酯衍生物等多种理化刺激所激活,参与维持细胞的正常功能。近年来,TRPV4在细胞增殖、分化、凋亡及迁移中的作用研究颇多,其异常表达与肿瘤的发生发展密切相关。笔者就该通道在肿瘤中的研究进展进行综述。

As a member of the transient receptor potential （TRP） channels family, TRPV4 is a non-selective cation channel. It can be activated by heat, mechanical forces, phorbol ester derivatives and other physicochemical stimuli, and then participate in the maintenance of normal cell function. In recent years, many studies have focused on the role of TRPV4 in cell proliferation, differentiation, apoptosis and migration. The abnormal expression of TRPV4 is closely related to the occurrence and development of tumors. In this paper the authors present the latest progress concerning TRPV4 channel in cancer.