还原型谷胱甘肽联合多烯磷脂酰胆碱治疗酒精性肝病的临床疗效及对肝功能的影响

Effect of Reduced Glutathione Combined with Polyene Phosphatidylcholine on Liver Function in Patients with Alcoholic Hepatitis

目的:探讨还原型谷胱甘肽联合多烯磷脂酰胆碱治疗酒精性肝病的临床疗效及肝功能的影响。方法:124例酒精性肝病患者随机分为对照组(n=62)和观察组(n=62),对照组在常规治疗的基础上,给予多烯磷脂酰胆碱;观察组在对照组的基础上,给予还原型谷胱甘肽。比较两组的临床疗效及肝功能变化。结果:观察组总有效率显著高于对照组(88.71%VS69.35%),差异有统计学意义(P<0.05);与治疗前比较,两组患者ALT、AST、TBIL及GGT水平均显著下降(P<0.05),且观察组下降更为明显(P<0.05)。结论:还原型谷胱甘肽联合多烯磷脂酰胆碱可显著改善患者酒精性肝病患者肝功能、临床症状和体征,值得应用。

Objective: To explore the effect of reduced glutathione combined with polyene phosphatidylcholine on liver function in patients with alcoholic hepatitis.Methods:124 cases of alcoholic hepatitis were divided into control group(n=62)and observation group(n=62). The patients of control group were given polyene phosphatidylcholine on the basis of conventional therapy. And the patients of observation group were given reduced glutathione on the basis of control group .The effect and liver function of two groups were compared.Results:The total effect rate of observation group were higher than in the control group(88.71%VS69.35%). The level of ALT, AST, TBIL and GGT were improved significantly in observation group after treatment(P<0.05), but which were not reduced significantly in control group(P<0.05).Conclusion:The reduced glutathione combined with polyene phosphatidylcholine can improve the liver function, clinical symptoms and signs in patients with alcoholic hepatitis. It’s worthy of clinic application.