期刊文献+
任意字段
题名或关键词
题名
关键词
文摘
作者
第一作者
机构
刊名
分类号
参考文献
作者简介
基金资助
栏目信息

微小RNA在肺部疾病中的作用

原文传递
导出
摘要 微小RNA（miRNA）作为关键的调控因子在多种疾病发生发展过程中发挥重要作用，成为生物医药领域的研究焦点。它是一类长约22～25个核苷酸的内源性非编码RNA，成熟的miRNA可以与靶基因mRNA的3’端非编码区互补结合，从而抑制靶基因翻译或促进靶基因mRNA降解。
作者 王欣 王延让 杨德一
机构地区 天津市疾病预防控制中心
出处 《中华劳动卫生职业病杂志》 CAS CSCD 2016年第1期68-71,共4页 Chinese Journal of Industrial Hygiene and Occupational Diseases
基金 国家自然科学基金资助项目（81102106） 中国博士后科学基金资助项目（2014M560l89） 天津市自然科学基金资助项目（15JCQNJCl0500、BJCZDJC30600）
关键词 肺部疾病 微小RNA 非编码RNA 基因MRNA miRNA RNA降解 调控因子 医药领域
分类号 R563 [医药卫生—呼吸系统]
  • 相关文献

参考文献34

  • 1van den Berge M, Steiling K, Timens W, et al. Airway gene expression in COPD is dynamic with inhaled cortieosteroid treatment and reflects biological pathways associated with disease activity[J]. Thorax, 2014, 69( 1 ):14-23.
  • 2Celli BR. Recommendations for the early diagnosis of COPD: the AIMAR view[J]. Muhidiscip Respir Med, 2015, 10( 1 ):6.
  • 3Tian Q, An Y, Xiao BB, et ah Treatment of giant emphysamous bulla with endobronchial valves in patients with chronic obstructive pulmonary disease: a case series[J]. J Thorac Dis, 2014, 6( 12): 1674-1680.
  • 4Ezzie ME, Crawford M, Cho JH, et al. Gene expression networks in COPD: microRNA and mRNA regulation[J] . Thorax, 2012, 67( 2 ): 122-131.
  • 5Hayashi H, Abdollah S, Qiu Y, et al. The MAD-related protein Smad7 associates with the TGFbeta receptor and functions as an antagonist of TGFbeta signaling[J]. Cell, 1997, 89 ( 7 ): l 165 - 1173.
  • 6Hassan F, Nuovo GJ, Crawford M, et al. MiR-101 and miR-144regulate the expression of the CFTR chloride channel in the lung[J]. PLoS One, 2012, 7( 11 ):e50837.
  • 7Graft JW, Powers LS, Dickson AM, et al. Cigarette Smoking Decreases Global MicroRNA Expression in Human Alveolar Macrophages[J]. PLoS One, 2012, 7(8 ):e44066.
  • 8Sato T, Liu X, Nelson A, et al. Reduced miR-146a increases prostaglandin Ezin chronic obstructive pulmonary disease fibrob- lasts[J]. Am J Respir Crit Care Med, 2010, 182(8):1020-1029.
  • 9Huang SK, Wettlaufer SH, Chung J, et al. Prostaglandin E2 inhibits specific lung fibroblast functions via selective actions of PKA and Epac-1 [J]. Am J Respir Cell Mol Biol, 2008, 39(4):482-489.
  • 10Akbas F, Coskunpinar E, Aynaci E, et al. Analysis of serum micro- RNAs as potential biomarker in chronic obstructive pulmonary disease[J]. Exp Lung Res, 2012, 38 (6):286-294.

二级参考文献24

  • 1刘艳红,范雪云.白细胞介素-6与纤维化疾病[J].中华劳动卫生职业病杂志,2006,24(2):126-128. 被引量：3
  • 2Chua J H. Armugam A, Jeyaseelan K. MicroRNAs: biogenesis, function and applications[J]. CmT Opin Mol Ther,2009.11:189-199.
  • 3Xie T, 1,iang J, Guo R, et al. Comprehensive microRNA analysis in bleomycin-induced pulmonary fibrusis identifies multiple sites of molecular regulation[J]. Physiol Genomics,2011,43:479-487.
  • 4Foss K M, Sima C, Ugolini D, et al. miR-1254 and miR-574-5p: serum-based microRNA biomarkers for early-stage non-small cell lung cancer[J]. J Thorac Oneol,2011,6:482-488.
  • 5Heegaard N H, Schetter A J, Welsh J A, et al. Circulating micro- RNA expression profiles in early stage nonsmall cell lung cancer[J]. Int J Caneer,2012,130:1378-1386.
  • 6Li D, Chen P, Li X Y, et al. Grade-specific expression profiles of miRNAs/mRNAs and docking study in human grade Ⅰ-Ⅲ astrocytomas[J]. OMICS,2011,15:673-682.
  • 7Luo Z, Zhang L, Li Z, et al. An in silieo analysis of dynamic changes in microRNA expression profiles in stepwise development of nasopharyngeal carcinoma[J]. BMC Med Genomies,2012,5:3.
  • 8Sehnitger AK, Machova A, Mueller RU, et al. Listeria monoeytogenes infection in macrophages induces vacuolar-dependent host miRNA response[J]. PLoS One,2011,6:e27435.
  • 9O' Neill L A, Bowie A G. The family of five: TIR-domain-eontaining adaptors in Toll-like receptor signalling [J]. Nat Rev Immunol, 2007,7:353-364.
  • 10Semik-Orzech A, Barczyk A, Pierzchala W. The role of interleukin 17 eytokine family in inducing allergic inflammation in the pulmonary tract[J]. Pneumonol Alergol Pol,2006,74:409-413.

共引文献30

中华劳动卫生职业病杂志
2016年 第1期

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部