绝经前乳腺癌患者中青年与非青年的临床病理分析

Clinicopathological features of premenopausal breast cancer patients between youth and non-youth

目的研究绝经前乳腺癌患者中青年与非青年患者的临床病理特点。方法收集行手术治疗的531例绝经前乳腺癌患者的完整病理资料,根据确诊时年龄是否〈40岁将其分为青年组和非青年组,并比较其病理类型、淋巴结转移情况、雌激素受体（ER）、孕激素受体（PR）、人类表皮生长因子受体-2（HER2）表达情况。结果绝经前乳腺癌患者中,青年组与非青年组患者病理类型均以浸润性导管癌为主,差异无统计学意义（χ^2=0.82,P〉0.05）,同时淋巴结转移情况、ER、PR和HER2的阳性表达情况也无统计学意义（χ~2分别=0.36、0.30、0.00、0.30,P均〉0.05）。结论绝经前乳腺癌,不论是否为青年期,其病理类型、淋巴结转移情况及ER、PR、HER2表达情况相似,在临床上均应得到重视。

Objective To study the clinicopathological features of premenopausal breast cancer patients between youth and non-youth. Methods Completed pathological data of 531 cases of premenopausal breast cancer were collected and divided into two groups according to whether they were younger than 40 years old or not. The pathological type, lymph node metastasis, expression of estrogen receptor（ER）, progesterone receptor（PR）, human epidermal growth factor receptor 2（HER2） were compared and analyzed. Results There was no statistical difference between two groups of patients in pathological type which were both constituted mainly by invasive ductal carcinoma（χ^2=0.82,P〈0.05）. As for lymph node metastasis, expression of ER, PR, HER-2 gene, there was also no statistical difference between the two groups（χ^2=0.36,0.30, 0.00, 0.30, P 0.05）. Conclusion The pathological type, lymph node metastasis and expression of ER, PR,HER2 gene of premenopausal breast cancer were similar no matter young or not. Therefore, the importance should be attached to all the premenopausal breast cancer clinically.