中西医结合治疗幽门螺杆菌阳性萎缩性胃炎的疗效及对核因子-κB表达的影响

Clinical effect of traditional Chinese medicine combined with western medicine on helicobacter pylori-positive atrophic gastritis and the influence to the nuclear factor-κB expression

目的探究中西医结合治疗幽门螺杆菌阳性萎缩性胃炎的临床疗效及对核因子-κB表达的影响。方法选取120例幽门螺杆菌阳性萎缩性胃炎患者进行前瞻性分析,随机分为单独西药组与中西医结合组,每组各60例,单独西药组给予吗丁啉、枸橼酸铋钾及克拉霉素治疗,中西医结合组在其基础上加用中药辩证治疗,比较两组患者临床疗效、胃液p H值变化、症状积分、幽门螺杆菌根除率及核因子-κB表达的情况。结果中西医结合组总有效率明显高于单独西药组,差异均有统计学意义（χ^2=5.45,P〈0.05）。中西医结合组治疗后胃液p H、核因子-κB蛋白较单独西药组治疗后相比明显降低,幽门螺杆菌根除率均明显高于单独西药组,差异均有统计学意义（t分别=2.66、3.78,χ~2=6.02,P均〈0.05）。中西医结合组胃肠、胃痛、嗳气、纳呆、嘈杂评分较单独西药组相比均明显降低,差异均有统计学意义（t分别=2.89、3.11、2.76、3.56、3.45,P均〈0.05）。结论采用中西医结合治疗幽门螺杆菌阳性萎缩性胃炎的临床疗效明显,核因子-κB表达降低。

Objective To explore the clinical effect of traditional Chinese medicine combined with western medicine on helicobacter pylori-positive atrophic gastritis and the influence to the nuclear factor- κB expression. Methods A total of 120 cases of helicobacter pylori-positive patients with atrophic gastritis were randomly divided into western medicine and combination of traditional Chinese medicine and western medicine group with 60 cases in each. Single western medicine group was given bismuth citrate, potassium and clarithromycin treatment, combination of traditional Chinese medicine and western medicine group was given traditional Chinese medicine dialectical treatment based on the western medicine. The clinical efficacy, gastric juice p H change, symptom integral, helicobacter pylori eradication rate and nuclear factor-κB were compared between two groups. Results The total effective rate of combination of traditional Chinese medicine and western medicine group was significantly higher than western medicine group（χ^2=5.45,P〈0.05）. After treatment, the gastric p H and nuclear factor- κB protein of combination of traditional Chinese medicine and western medicine group were significantly lower than western medicine group while helicobacter pylori eradication rate was significantly higher than single western medicine group（t =2.66, 3.78,χ^2=6.02,P〈0.05）. In combination of traditional Chinese medicine and western medicine group, the gastric bowel, stomach pain, belching, stay, noisy score were significantly lower than western medicine group（t=2.89, 3.11, 2.76, 3.56, 3.45, P0.05）. Conclusion The clinical effect of traditional Chinese medicine combined with western medicine on helicobacter pylori-positive atrophic gastritis is obvious.