S100A8、S100A9蛋白在急性肺损伤新生儿血清中的动态变化及意义

Dynamic changes and clinical significance of serum S100A8 and S100A9 protein in newborns with acute lung injury

目的探讨S100A8、S100A9蛋白在急性肺损伤(ALI)新生儿血清中的动态变化。方法选择该院2011年1月至2013年12月收治的ALI患儿30例(ALI组)、湿肺患儿30例(湿肺组)及同期产科出生的健康新生儿30例(对照组),采取酶联免疫吸附测定(ELISA)法分别检测各组对象S100A8及S100A9蛋白的动态变化。结果ALI组在发病第1、3、7天血清S100A8、S100A9蛋白均明显高于湿肺组及对照组,差异有统计学意义(P<0.01),ALI组S100A8蛋白在发病第1天升高最为明显[(187.29.±29.71)pg/mL],S100A9蛋白在发病第3天升高最为明显[(280.01±42.29)pg/mL],差异有统计学意义(P<0.01),第7天时二者均有不同程度下降。湿肺组S100A8、S100A9蛋白较对照组升高,但差异无统计学意义(P>0.05)。结论S100A8、S100A9蛋白参与了新生儿ALI的发病,对新生儿ALI早期诊断、治疗及预后有着一定的潜在临床应用价值。

Objective To study the dynamic changes of serum S100A8 and S100A9protein in newborns with acute lung injury（ALI）.Methods Thirty newborns with ALI（ALI group）were enrolled in this study,30 newborns with wet lung（wet lung group）and 30 healthy newborns（control group）were selected.The changes of serum S100A8 and S100A9protein levels were detected by the enzyme linked immunosorbent assay（ELISA）.Results The levels of serum S100A8 and S100A9protein on 1,3,7d after ALI onset in the ALI group were significantly higher than those in the wet lung group and the control group,the difference was statistically significant（P〈0.01）.The increase of serum S100A8 protein level in the ALI group was most significant on 1dafter onset[（187.29.±29.71）pg/mL],while which of serum S100A9 was most obvious on 3dafter onset[（280.01±42.29）pg/mL],the differences were statistically significant（P〈0.01）,both were decreased to some extent on 7d.The serum S100A8 and S100A9protein levels in the wet lung group were higher than those in the control group without statistical difference（P〈0.05）.Conclusion S100A8 and S100A9protein are involved in the pathogenesis of ALI,which have certain potentially clinical application value in the early diagnosis,treatment and prognosis of ALI.