冠心病与非酒精性脂肪性肝病的相关性分析

Analysis on correlation between coronary heart disease and non-alcoholic fatty liver disease

目的探讨冠心病(CHD)与非酒精性脂肪性肝病(NAFLD)的相关性。方法选择疑诊冠心病(CHD)患者199例,根据经冠状动脉造影(CAG)诊断分为两组:CHD患者132例(观察组)和非CHD患者67例(对照组);观察两组患者的基本情况、生化指标、CAG并行冠状动脉Gensini评分、肝脏超声。结果观察组和对照组基本情况分别为:男女所占比例98/34和40/27、吸烟率53.79%和37.76%、高血压患病率79.55%和50.75%、2型糖尿病(T2DM)患病率56.06%和31.34%、总胆固醇(TC)(4.49±0.49)mmol/L和(4.07±0.89)mmol/L、三酰甘油(TG)(2.28±0.76)mmol/L和(1.42±0.51)mmol/L、低密度脂蛋白胆固醇(LDL-C)(2.72±0.82)mmol/L和(2.26±0.44)mmol/L,观察组均高于对照组(P<0.01);观察组中NAFLD发生率(60.61%)明显高于对照组(35.82%),两组比较差异有统计学意义(P<0.01);合并患有NAFLD的CHD患者以多支病变为主(P<0.05),且病变程度较重。结论 NAFLD可作为CHD相关危险因素,且预示CHD较为严重。

Objective To investigate the correlation between coronary heart disease（CHD）and non-alcoholic fatty liver disease（NAFLD）.Methods A total of 199 patients with suspected CHD were selected and divided into the observation group（132cases of CHD）and the control group（67cases of non-CHD）according to the diagnosis of coronary angiography（CAG）.The general information,blood biochemical indicators,CAG,Gensini′s score and hepatobiliary ultrasonography were observed in the two groups.Results In the basic information of the observation group and the control group：the ratio of male to female was 98/34and40/27,the smoking rate was 53.79% and 37.76%,the prevalence rate of hypertension was 79.55% and 50.75%,the prevalence rate of type 2diabetes mellitus（T2DM）was 56.06%and 31.34%,TC was（4.49±0.49）mmol/L and（4.07±0.89）mmol/L,TG was（2.28±0.76）mmol/L and（1.42±0.51）mmol/L and LDL-C was（2.72±0.82）mmol/L and（2.26±0.44）mmol/L,the observation group was significantly higher than the control group（P〈0.01）.The incidence rate of NAFLD in the observation group was significantly higher than that in the control group（60.61%vs.35.82%,P〈0.01）.Most of the patients with CHD complicating NAFLD had multi-vessel lesions in the coronary artery（P〈0.05）,moreover the lesion severity tended to be more severe.Conclusion NAFLD can be used as a related risk factor for CHD and predicts that CHD is relatively severe.