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内质网应激与微小核糖核酸在胰岛β细胞凋亡中的作用

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摘要 胰岛β细胞功能障碍是2型糖尿病由临床前期向临床期进展的关键环节,主要表现为胰岛素合成分泌的减少以及胰岛β细胞数量的下降。研究显示,2型糖尿病患者的胰岛β细胞数量较同体重指数的肥胖以及非肥胖人群分别减少63%及41%,而β细胞凋亡水平分别是肥胖及非肥胖人群的3倍和10倍[1],因此胰岛β细胞凋亡在2型糖尿病发生发展中具有十分重要的作用。
作者 吉慧珍 孙琦 杨静 邢小平
机构地区 中国医学科学院北京协和医学院北京协和医院内分泌科卫生部内分泌重点实验室 山西医科大学附属第一医院内分泌科
出处 《协和医学杂志》 2016年第1期48-52,共5页 Medical Journal of Peking Union Medical College Hospital
关键词 内质网应激 微小核糖核酸 胰岛Β细胞 凋亡
分类号 R587.1 [医药卫生—内分泌] Q756 [生物学—分子生物学]
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参考文献41

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协和医学杂志
2016年 第1期

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