儿童血清25-羟维生素D水平与超声骨密度关系研究

Relationship Between Serum 25-hydroxyvitamin D and Ultrasonic Bone Mineral Density in Children

目的调查分析儿童血清维生素D营养状况及与超声骨密度关系，为科学合理补充维生素D及钙剂提供依据。方法选取儿保科门诊常规体检的1～10岁儿童368名为研究对象，采用化学发光法测定血清25-羟维生素D水平，定量超声骨密度仪测取骨密度值。结果所选儿童血清25-羟维生素D平均水平为（28．3±12）ng／ml，超声骨密度平均水平为（-0．07±0．10）。随着年龄增加，维生素D水平逐渐下降，25-羟维生素D缺乏组、不足组中超声骨密度不足率均较充足的组别高（P〈0．05），男女童25-羟维生素D及超声骨密度均值比较无统计学意义（P〉0．05）。6～岁年龄组25一羟维生素D与骨密度呈正相关（P〈0．05）。结论泸州市儿童25-羟维生素D及超声骨密度普遍不足，两者仅在一定年龄可能有关，临床上应结合两种检查，科学合理补充维生素D及钙剂。

Objective To explore the relationship between serum 25-hydroxyvitamin D [25（OH）D] and ultrasonic bone mineral density （BMD） in children so as to provide basis for scientific and reasonable supplement of vitamin D and calcium. Methods 368 children were selected from the clinic of Department of Pediatric Health Care; the level of serum 25（OH）D was measured by while the individual BMD was measured by quantitative ultrasound. Results The average level of serum 25（OH）D was （28.36± 12）ng/ ml while the average Z value of ultrasonic BMD was （-0.07±0.10）; the level of 25（OH）D kept decreasing with the age growing; the low rate of ultrasonic BMD in children with vitamin D deficiency or with low level of vitamin D was higher than that of children with suffi- cient vitamin D （P〈0.05）, the comparative study between the average level of serum 25（OH）D and the average Z value of BMD was of no statistical significance （P〉0.05）; there existed a positive correlation between the level of serum 25（OH）D and the Z value of BMD in children aged from 6 to 7 years old （P〈0.05）. Conclusions The level of serum 25（OH）D and the Z value of ultrasonic BMD of children in Luzhou City, Sichuan Province are low while the correlation between the 2 exists in certain age stages; the combination of the 2 detections may be of help for the scientific and reasonable supplement of vitamin D and calcium in clinic.