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重组人血小板生成素及白介素-11应用于白血病化疗所致血小板减少症的系统评价 被引量:25

Meta-analysis of recombinant human thromobopoietin and recombinant human interleukin-11 in the treatment of chemotherapy induced thrombocytopenia
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摘要 目的评价重组人血小板生成素(rh TPO)及重组人白细胞介素-11(rh IL-11)应用于白血病化疗后血小板减少症的有效性与安全性。方法采用循证医学的方法,计算机检索中国知网(1997-2015年1月)、万方数据资源系统(1977-2015年1月)、中国科技期刊数据库(1989-2015年1月),收集rh TPO和rh IL-11治疗白血病化疗后血小板减少症的所有平行对照试验。结果共纳入7篇文献。与rh IL-11组相比,rh TPO能增加白血病患者恢复血小板的最高值,缩短白血病患者化疗后血小板≤50×10^9/L的持续时间,缩短白血病患者化疗后恢复至血小板≥75×10^9/L的时间(均P〈0.00001);rh TPO组不良反应发生率更低[RR 0.19,95%CI(0.12-0.31),P〈0.00001]。但rh TPO组和rh IL-11组患者化疗后血小板的最低值及rh TPO组和rh IL-11组恢复至血小板≥100×10^9/L的时间无明显差异。结论在治疗白血病化疗后血小板减少症方面,与rh IL-11组相比,rh TPO能够增加血小板恢复的最高值、缩短血小板≤50×10^9/L的持续时间和恢复至血小板≥75×10^9/L的时间,并减少不良反应的发生。但二者对改善化疗后血小板的最低值和使患者恢复至血小板≥100×10^9/L的时间方面差异无统计学意义。然而,目前的临床试验设计存在不足,需要设计完善的大样本随机对照试验进行验证。 Objective To assess the effectiveness and the safety of recombinant human thromobopoietin(rhTPO) and recombinant human interleukin-11 (rhIL-11 ) in the treatment of chemotherapy induced thromboeytopenia. Methods Computer retrieval was conducted to search for randomized controlled studies in which rhTPO was compared with rhIL-11 in chemotherapy induced thrombocytopenia in CNKI( 1997 to January,2015) ,WANFANG DATA( 1977 to January,2015) ,and CSTJ( 1989 to January,2015). The results were analyzed by using RevMan5.2.4 software according to the methods of evidence based medicine. Results A total of 7 literatures were included. Compared with rhIL-11, rhTPO could further increase the maximum value of blood platelet, shorten the time interval of blood platelet less than 50×10^9/L and the time for blood platelet elevating above 75 ×10^9/L( all P 〈 0. 00001 ). In addition, the incidence of adverse drug reactions was low in rhTPO group(RR=0. 19,95% CI =0. 12 - 0. 31 ,P 〈 0. 00001 ). However,there was no significant difference in the improvement of minimum value of blood platelet after chemotherapy and in the duration of platelet recovery ≥ 100×10^9/L between the two drugs. Conclusion The rhTPO can improve maximum platelet count recovery, shorten the duration of platelet count ≤50×10^9/L, speed up platelet recovery ≥〉 75×10^9/L and indirectly reduce ADR in the treatment of chemotherapy induced thrombocytopenia when compared with rhIL-11. However, large-scale trials with perfect design are needed to confirm the results since there are insufficient designs in all the current clinical trials.
出处 《实用医院临床杂志》 2016年第1期110-114,共5页 Practical Journal of Clinical Medicine
关键词 重组人血小板生成素 白介素-11 白血病 血小板减少 Recombinant human thromobopoietin ( rhTPO ) Recombinant human interleukin-11 ( rhIL-11 ) Leukemia Thrombocytopenia
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  • 1白春梅,赵永强,韩少梅,邹晓阳,单渊东.重组人血小板生成素治疗白血病患者化疗诱导血小板减少73例[J].中国新药杂志,2004,13(6):555-559. 被引量:5
  • 2白春梅,徐光勋,赵永强,韩少梅,单渊东.重组人血小板生成素治疗实体肿瘤患者化疗后血小板减少的多中心临床试验[J].中国医学科学院学报,2004,26(4):437-441. 被引量:37
  • 3黄梅,张东华,孙汉英,邓金牛,周剑锋,刘文励.应用重组人血小板生成素(rhTPO)临床观察[J].中国血液流变学杂志,2005,15(1):105-107. 被引量:19
  • 4段朝霞,侯丽虹,杨林花.重组人白细胞介素-11治疗急性白血病化疗后血小板减少的疗效观察[J].中国药物与临床,2006,6(7):496-498. 被引量:3
  • 5Tijsscn MR,Van der Schoot CE,Voermans C,et al.Clinical approaches involving thrombopeietin to shorten the period of thrombocytopenia after high-dose chemotherapy[J].Trans Med Rev,2006; 20:283-293.
  • 6Corazza F,Hermans C,D Hendt S,et al.Blood.Circulating thrombopoietin as an in vivo growth factor for blast cells in acute myeloid leukemia[J].Blood,2006 ; 107:2525-2530.
  • 7Tijssen MR,di Summa F,Van den Oudenrijn S,et al.Functional analysis of single amino-acid mutations in the thrombopoietin-receptor Mpl underlying congenital amegakaryocytic thrombocytopenia[J].Br J Haematol,2008;141:808-813.
  • 8Bhatia M,Davenport V,Cairo MS.The role of interleukin-11 to prevent chemotherapy-induced thrombocytopenia in patients with solid tumors,lympboma,acute myeloid leukemia and bone marrow failure syndromes[J].Leukemia Lymphoma,2007;48:9-15.
  • 9Calm MS.Phase Ⅰ/Ⅱ dose escalation study of recombinant human interleukin-11 following ifosfamide,carboplatin and etoposide in children,adolescents and young adults with solid tumours or lymphoma:a clinical,haematological and biological study[J].Bri J Haematol,2005 ;128:49-58.
  • 10张之南,沈悌.血液病诊断与疗效标准[M].3版.北京:科学出版社,2007:116-121.

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