摘要
目的:探讨FTOrs9939609突变基因型TA/AA对超重与肥胖大学生的形态和糖代谢相关指标的影响。方法:为150名自愿参与的上海某高校大一学生测量其形态以及体脂等指标,分析血糖和胰岛素水平,估算胰岛素抵抗水平。结果:超重与肥胖大学生rs9939609多态性等位基因频率与一般人群基本一致,FTOrs9939609TA/AA基因型对超重与肥胖青少年的形态与身体成分具有影响,FTOrs9939609位点的A等位基因更易于发生胰岛素抵抗。
The aim of the study was to examine the effects of FTO single - nucleotide polymorphism （SNP） rs9939609 on anthropometrics and glucose metabolism in overweight and obesity college students. Methods：One hundred and fifty male overweight or obese students were recruited from a university in Shanghai, China. Anthropometrics were measured by standard procedures. Glucose and insulin was analyzed in serum. Insulin resistance was esti- mated by the homeostasis model assessment insulin resistance. Results：Compared with the TT carriers, the TA/AA carriers had significant higher BMI, visceral fat index （ VFI ） , chest circumference （CC）,waist circumference （WC） ,hip circumference （HC）,thigh circumference （ TC ） , glucose, insulin and HOMA - IR （ all P 〈 0.05 ）. Conclusions ： The frequency of FTO rs9939609 genetic variants is consistent with the general population, the FTO rs9939609 variants are associated with body composition and insulin resistance.
出处
《哈尔滨体育学院学报》
2015年第6期20-23,30,共5页
Journal of Harbin Sport University
