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氟哌利多抑制吗啡成瘾大鼠尾核内p-CREB的表达

Droperidol inhibits morphine-induced increase of p-CREB in the caudate nucleus of rats
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摘要 目的探讨氟哌利多对吗啡成瘾大鼠尾核内磷酸化c AMP反应元件结合蛋白(p-CREB)表达的影响。方法大鼠皮下注射递增剂量吗啡,建立吗啡成瘾动物模型。然后侧脑室注射氟哌利多,用免疫组织化学方法测定尾核内p-CREB表达。结果大鼠吗啡成瘾后,尾核内p-CREB表达增加;侧脑室注射氟哌利多后,成瘾大鼠尾核内p-CREB表达降低。结论尾核参与吗啡成瘾的过程。氟哌利多抑制吗啡成瘾诱导的尾核内p-CREB表达。 Objective To determine the effects of droperidol on the p-CREB expression in the caudate nucleus of morphine dependent rats. Methods A physical dependent model in rats was established by subcutaneous injection of morphine. Droperidol was injected into lateral ven- tricles. The levels of p-CREB in the caudate nucleus of morphine dependent rats were detected by immunohistochemistry method. Results The levels of p-CREB in the caudate nucleus of morphine dependent rats were increased. After the administration of droperidol, the expression of p-CREB in the caudate nucleus of morphine dependent rats was decreased. Conclusion The caudate nucleus maybe involves in the morphine dependence. Droperidol inhibits mor- phine-induced increase of p-CREB in the caudate nucleus.
作者 常金龙 尹世琦 刘晓宇 王然 王娇 张颖
机构地区 哈尔滨医科大学生理学教研室 黑龙江省电力医院内科
出处 《哈尔滨医科大学学报》 CAS 2015年第6期486-488,共3页 Journal of Harbin Medical University
基金 黑龙江省留学归国科学基金项目(LC2012C20)
关键词 吗啡 成瘾 尾核 CAMP反应元件结合蛋白 氟哌利多 morphine dependent caudate nucleus CREB droperidol
分类号 R338 [医药卫生—人体生理学]
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参考文献10

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哈尔滨医科大学学报
2015年 第6期

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