摘要
目的:探讨稳定型心绞痛患者口服尼可地尔对冠状动脉微循环阻力指数(IMR)影响。方法:入选以稳定型心绞痛入院并拟行择期经皮腔内冠状动脉介入术(PCI)的患者50例,加拿大心脏病学会的劳力性心绞痛分级<Ⅳ级。将患者随机分为尼可地尔组(n=25)和对照组(n=25),在择期PCI术前均常规使用双联抗血小板、他汀类药物和其他治疗冠心病相关药物。尼可地尔组口服尼可地尔5 mg、3次/d,30 d;对照组口服硝酸异山梨酯5 mg、3次/d,30 d。在行PCI术后,立刻以压力导丝检测两组患者的IMR,比较2组PCI术后IMR的差异。结果:2组患者间PCI术前基线临床特征、术前一般用药情况及PCI术中相关参数无显著统计学差异。PCI术后尼可地尔组IMR显著低于对照组,为16.89±4.70对26.26±8.63,P<0.001;PCI术后IMR≥22患者所占比例尼可地尔组显著低于对照组,为5/25对12/25,P=0.036。结论:对于拟行择期PCI术的稳定型心绞痛患者,术前服用尼可地尔可改善冠状动脉微循环。
Objective： To assess the impact of nieorandi[ pre-treatment on the index of microcirculatory resistance （IMR） values in patients with stahle angina peetoris undergoing percutaneous coronary intervention （PCI）. Methods： A total of 50 consecutive patients with stable angina undergoing PCI were enrolled in this study. Patients were randomly assigned to the nicorandil treatment （5 mg, three times a day, n= 25） or Isosorbide Dinitrate treatment （5 rag, three times a day, n= 25） groups 30 days before selected PCI. IMR was measured using the intracoronary pressure/temperature sensor-tipped guide after successful PCL The IMR values were compared between the nicorandil group and control group. Results： IMR values were significantly lower in thenicorandil group than in the control group （16. 89 ±4. 70 vs. 26. 26±8. 63, P〈0. 001）. There were 5 patients with IMR≥22 in the nicorandil group and 12 patients in the control group （P = 0. 036）. However, the baseline clinical and procedural variables were similar in the nicorandil group and control group. Conclusion：In patients undergoing PCI for stable angina, pre-treatment with nicorandil was associated with reduced microvascular dysfunction induced by PCI.
出处
《国际心血管病杂志》
2015年第6期412-415,共4页
International Journal of Cardiovascular Disease
基金
湖南省科技厅资助科研项目(2012SK3028)
湖南省卫生厅资助项目(B2013-138)
