神经节苷脂在新生儿缺血缺氧性脑病治疗中的应用效果分析

Analysis of the Effect of the Application of Gangliosides in the Treatment of Neonatal Hypoxic Ischemic Encephalopathy

目的探讨神经节苷脂对新生儿缺血缺氧性脑病的临床治疗效果。方法选取2012年6月~2015年6月在我院接受治疗的新生儿缺血缺氧性脑病患者84例作为此次研究对象,将所选取的84例患者随机分为治疗组与对照组,每组患者42例。治疗组与对照组患者均全部使用综合治疗方法,治疗组的42例患儿在此基础上加用神经节苷脂静脉点滴,每天20 mg,1次/d,7~10 d为1个疗程。结果此次研究,治疗组42例患者中,治疗显效33例（78.57%）,治疗有效5例（11.90%）,总有效率为90.47%。对照组的42例患者中,治疗显效11例（26.19%）,治疗有效15例（35.71%）,治疗总有效率为61.90%,治疗组与对照组总有效率对比差异有统计学意义,P〈0.05。结论使用神经节苷脂可以有效促进新生儿缺血缺氧性脑病患者的临床症状恢复,同时没有副作用。

Objective To investigate the clinical effects of gangliosides on neonatal hypoxic-ischemic encephalopathy. Methods 84 newborns with hypoxicischemic encephalopathy from June 2012 to June 2015 in our hospital were treated as the research objects. They were randomly divided into treatment group and control group,with 42 patients in each group. The two groups were all using an integrated treatment,42 patients in the treatment group based on the use of this and add with ganglioside intravenous daily 20 mg,once a day,7 ~ 10 days for a course. Results In the study of 42 cases of treatment group,33 patients cured excellent（78.57%）,effective was 5 cases（11.90%）,the total efficiency was 90.47%. In the control group with 42 cases,the patients cured excellent was 11 cases（26.19%）,effective was 15 cases（35.71%）,total effective rate was 61.90%,the difference between the treatment group and the control group was statistically significant,P〈0.05. Conclusion Ganglioside can effectively promote clinical symptoms of neonatal hypoxic-ischemic encephalopathy in patients,and there is no obvious side effects.