吡格列酮和拜糖平治疗2型糖尿病的疗效

Efficacy of pioglitazone and acarbose in patients with type 2 diabetes mellitus

目的比较吡格列酮和拜糖平治疗2型糖尿病(T2DM)的疗效。方法 T2DM患者150例随机均分为两组:P组每日早餐前口服吡格列酮30mg;A组餐前服用拜糖平0.1g,每日3次。连续治疗3个月后,复查空腹血糖(FBG)、餐后2h血糖(2hBG)和糖化血红蛋白A1c(HbA1c),比较两组疗效。结果连续治疗3个月后,P组FBG低于A组[(7.2±1.5)mmol/L vs.(8.6±1.9)mmol/L](P<0.05),但P组2hBG高于A组[(13.0±2.6)mmol/L vs.(10.6±2.2)mmol/L)](P<0.05)。P、A两组HbA1c水平相仿[(7.4±1.1)%vs.(7.5±1.2)%](P>0.05)。结论吡格列酮与拜糖平均能有效控制T2DM患者的血糖水平;吡格列酮控制FBG的效果优于拜糖平,而拜糖平控制2hBG的效果优于吡格列酮。

Objective To compare the efficacy of pioglitazone and acarbose in the patients with type 2 diabetes mellitus（T2DM）.Methods A total of 150 patients with T2 DM was equally randomized into two groups.The patients in group P were treated with pioglitazone 30 mg per day before breakfast and those in group A with acarbose 0.1g three times a day before a meal.The fasting blood glucose（FBG）,blood glucose at two hours after a meal（2hBG）and glycosylated hemoglobin A1c（HbA1c）were measured after treatment for three months.The efficacy was compared between two groups.Results After treatment for three months,FBG was lower in group P than that in group A[（7.2±1.5）mmol/L vs.（8.6±1.9）mmol/L]（P〈0.05）,but 2hBG was higher in group P than that in group A[（13.0±2.6）mmol/L vs.（10.6±2.2）mmol/L）]（P〈0.05）.The levels of HbA1 cof two groups were similar[（7.4±1.1）% vs.（7.5±1.2）%]（P〉0.05）.Conclusion Both of pioglitazone and acarbose can effectively control blood glucose level in the patients with T2 DM,for which pioglitazone is better than acarbose in the control of FBG and acarbose is better than pioglitazone in the control of 2hBG.