糖基化白蛋白及超敏C-反应蛋白在2型糖尿病合并冠心病中的作用

Role of glycated albumin and high-sensitivity C-reactive protein in patients with coronary heart disease and type 2 diabetes mellitus

目的探讨糖基化白蛋白(GA)和超敏C-反应蛋白(Hs-CRP)在2型糖尿病合并冠心病患者中的作用。方法选择284例糖尿病患者行冠状动脉(冠脉)造影检查,其中211例为糖尿病合并冠心病且至少1支血管狭窄≥70%组,选择73例单纯糖尿病患者作为对照组,比较2组患者GA及Hs-CRP的变化水平。结果糖尿病合并冠心病组GA和Hs-CRP显著升高[GA为(21.23±0.35)%与(18.94±0.49)%,Hs-CRP为(17.30±1.02)mmol/L与(8.57±0.90)mmol/L](P<0.05);随冠脉病变血管支数增加,GA显著增高,Hs-CRP无明显变化(P>0.05)。结论 GA和Hs-CRP在糖尿病合并冠心病患者发病中具有重要作用。

Objective To explore the influence of glycated albumin （GA） and high- sensitivity C -reactive protein（HsCRP） levels on patients with coronary heart disease and type 2 diabetes mellitus. Methods 284 cases of type 2 diabetes mellitus with coronary angiography （CAM） were included in the study ,211 diabetes mellitus with coronary heart disease which at least one vascular stenosis ≥ 70% as experimental group （ Group I） ,and 73 patients with pure diabetes were served as a control group （ Group II）. The changes of the levels of glycated albumin and C - reactive protein in the 2 groups was compared. Serum levels of Serum GA levels were determined with an improved bromocresol purple method, and HsCRP was determined using high - sensitivity ELISA. Results GA and HsCRP levels were significantly higher in Group I than the control group. GA： （21. 23 ± 0. 35） % vs. （18. 94 ± 0. 49）% and HsCRP： （ 17.30 ± 1.02 ） mmol/L vs. （ 8.57 ± 0.90） mmol/L （ P 〈 0.05 ）. GA was significantly increased with the number increases of coronary arteries （P 〉 0.05）, but was not related to HsCRP level. Conclusion GA and HsCRP may play an important role in the development of coronary heart disease in patients with type 2 diabetes.