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泛素连接酶Hrd1与呼吸系统疾病 被引量：1

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摘要 肺部的细胞在受到缺氧、烟雾等外界刺激时会发生内质网应激（endoplasmic reticulum stress,ERS）,而ERS参与多种肺部疾病的发生发展-[1]。羟甲基戊二酰辅酶A还原酶降解蛋白1（Hmg-Co A reductase degradation 1,Hrd1）为一个六次跨膜的内质网膜蛋白,其生物学功能是作为E3泛素连接酶参与内质网相关性降解（ER-associated degradation,ERAD）。
作者 陈文琼 胡瑞成 戴爱国
机构地区 南华大学附属省马王堆医院 湖南省老年医院呼吸疾病研究所
出处 《中国呼吸与危重监护杂志》 CAS 北大核心 2016年第1期99-101,共3页 Chinese Journal of Respiratory and Critical Care Medicine
基金 国家自然科学基金(编号:81070035) 湖南省科技计划(编号:2009JT3054) 湖南省卫生厅科研基金(编号:B2008-026)
关键词 内质网膜蛋白 泛素连接酶 呼吸系统疾病 endoplasmic Hrd1 reticulum 酶降解 CFTR REDUCTASE 结构域
分类号 R56 [医药卫生—呼吸系统]
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参考文献31

  • 1苏建禄,胡瑞成,戴爱国.内质网应激与肺疾病研究进展[J].山东医药,2013,53(14):83-86. 被引量：5
  • 2Hampton RY, Gardner RG, Rine I. Role of 26S proteasome and HRD genes in the degradation of 3-hydroxy-3-methylglutaryl-CoA reductase, an integral endoplasmic reticulnm membrane protein.Mol Biol Cell, 1996,7:2029-2044.
  • 3王花枝,姜迪譞,胡瑞成,戴爱国.内质网相关性降解与呼吸系统疾病[J].国际呼吸杂志,2014,34(7):555-560. 被引量：3
  • 4Bordallo J, Plemper RK, Finger A, et al. Der3p/Hrdl p is required for endoplasmic reticulum-associated degradation of misfolded lumenal and integral membrane proteins. Mol Biol Cell, 1998,9: 209-222.
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二级参考文献16

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中国呼吸与危重监护杂志
2016年 第1期

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