不同阶段2型糖尿病患者血清脑钠肽水平

Research on Correlation Between Brain Natriuretic Peptide and Type 2 Diabetic Nephropathy

目的:探讨不同阶段2型糖尿病患者血清中脑钠肽(BNP)水平的改变。方法:2型糖尿病患者75例,按尿微量白蛋白(Alb)/肌酐(Cr)值分为正常蛋白尿组(Alb/Cr<30 mg/g),微量蛋白尿组(30 mg/g≤Alb/Cr<300 mg/g),大量蛋白尿组(Alb/Cr≥300 mg/g),采用罗氏电化学发光法检测3组患者血清BNP水平,分析不同阶段2型糖尿病BNP水平的变化,检测Cr、胱抑素-c(Cys-c)、尿素氮(UREA)等血生化指标。结果:微量蛋白尿组和大量蛋白尿组BNP水平均明显高于正常蛋白尿组,大量蛋白尿组高于微量蛋白尿组,差异有统计学意义(P<0.05);Cr、Cys-c、UREA在对照组、微量蛋白尿组和大量蛋白尿组和呈升高趋势,差异有统计学意义(P<0.05)。结论:随着2型糖尿病患者肾功能的下降BNP水平升高。

Objective： To investigate correlations of BNP levels with renal functions, glucose, lipids and other factors by measuring BNP levels of Type 2 diabetic patients. Methods： Seventy-five diabetics who received treatment from February 2013 to July 2014 in our department and conformed to inclusion standards. 75 diabetics in the diabetes group were further divided into three small groups： the normal- buminuric group （ UmAlb/C 〈 30 mg/g） with 25 cases, the microalbuminuric group （30 mg/g ≤ Um- Alb/C 〈300 mg/g） with 31 cases, and the macroalbuminuric group（ UmAlb/C≥300 mg/g） with 19 cases. Results： The BNP levels of patients in the microalbuminuric group and macroalbuminuric group were significantly higher than the BNP level of patients in the normalbuminuric group, while and the BNP level of patients in the macroalbuminuric group were significantly higher than the BNP level of patients in the microalbuminuric group, which indicated statistical significance （P 〈 O. 05 ）. Conclu- sions： BNP levels of Type 2 diabetic nephropathy patients were quite high. Type 2 diabetics with normal albuminuria, micro albuminuria and macro albuminuria showed significant differences in their BNP levels.