肺源性心脏病病程中脑钠肽水平变化的临床意义分析

Clinical Significance of Changes in the Level of Brain Natriuretic Peptide in Patients with Pulmonary Heart Disease

目的:探讨脑钠肽(BNP)水平变化在肺源性心脏病病程中的临床意义。方法:选取本院收治的慢性肺心病患者67例,根据病程的进展分为发作期和缓解期。采用双抗夹心免疫酶法测定BNP水平,血气分析测定PaO_2和PaCO_2水平,比较患者不同时期的血浆BNP、PaCO_2及PaO_2水平。结果:患者发作期BNP及PaCO_2水平分别为(215.83±83.17)ng/L和(52.13±5.38)mm Hg,明显高于缓解期,差异均有统计学意义(P<0.05);患者发作期PaO_2水平为(51.29±4.70)mm Hg,明显低于缓解期,差异有统计学意义(P<0.05)。结论:在肺源性心脏病患者的病程进展中,血浆BNP参与肺心病的病理生理过程,可作为评估患者疗效和判定预后的参考指标。

Objective：To investigate the clinical significance of brain natriuretic peptide（BNP） levels in the course of pulmonary heart disease. Method： 67 patients with chronic pulmonary heart disease in our hospital were selected, according to the progress of the disease course they were divided into episodes stage and remission stage.The BNP level was detected by double anti sandwich immunoassay, PaO_2 and PaCO_2 levels were determined by blood gas analysis. The different periods levels of BNP, PaCO_2 and PaO_2 were compared.Result：The episodes stage levels of BNP and PaCO_2 were respectively（215.83±83.17）ng/L and（52.13±5.38）mm Hg,they were significantly higher than the remission stage levels,the differences were statistically significant（P〈0.05）. The episodes stage levels of PaO_2 was（51.29±4.70）mm Hg,which was significantly lower than that in remission stage, the difference was statistically significant（P〈0.05）. Conclusion：In the course of pulmonary heart disease, BNP is involved in the pathophysiological process of pulmonary heart disease, which can be used as a reference index to evaluate the curative effect and prognosis.