碳包铁纳米粒子的靶向磁感应发热性能

Targeting Magnetic Induction Heating of Carbon-coated Iron Nanoparticles

采用直流电弧法制备一种新型的磁靶向药物载体材料——碳包铁纳米粒子并通过透射电子显微镜和X射线衍射仪对其微观形貌和结构进行了观察和表征。通过注射注入法和挖孔填入法将碳包铁纳米粒子置入原块猪肝中，研究了不同铁含量和不同浓度的碳包铁纳米粒子的磁感应发热性能。结果表明均匀球形、平均粒径10～30nm的碳包铁纳米粒子，其含量越高，磁感应发热效果越明显；碳包铁纳米粒子与生理盐水混合后注射注入原块猪肝中的发热温度高于直接将碳包铁纳米粒子挖孔填入猪肝的发热温度；感应电场的作用时间越长，发热越强，但有一个最高温度的饱和值；铁含量80％的样品30min后可达到51℃，足以杀死癌细胞。作为一种新型的磁靶向药物载体，碳包铁纳米粒子在癌症治疗中有望起到增强疗效和减少副作用的效果。

A type of magnetic targeting drug carrier material carbon coated iron nanoparticles were prepared by carbon arc method; their morphology and structure were analyzed by transmission electron microscope and X ray diffraction. By injecting method and filling method, the magnetic induction heating performance of carbon coated iron nanoparticles in pork liver were studied under the condition of different iron content in carbon coated iron nanoparticles and different carbon coated iron nanoparticles concentration in physiological saline. The results show that carbon coated iron nanoparticles are spherical and 10--30 nm in size. The more particles in pork liver, the effect of magnetic induction heating are more obvious. The heating temperature of injecting method is higher than that of filling method. The working time of induced electric field is longer, the heating is stronger, although there is a saturation value of highest temperature. With iron content of 80%, the heating temperature can go up to 51 ℃ after 30 min and that is high enough to kill the cancer cell. As a kind of magnetic targeting drug carrier material, carbon coated iron nanoparti- cles are expected to enhance the efficacy and reduce the side effect in cancer treatments.