摘要
目的:探讨中药联合细胞因子诱导的杀伤细胞(CIK细胞)调控肿瘤细胞的机制,为中药联合CIK细胞治疗癌症的机制研究提供思路。方法:检索中国期刊全文数据库(CNKI)、万方数字化期刊全文数据库、PudMed文献数据库,分别查找中药和CIK细胞调控肿瘤细胞的机制,并查找及探讨两者联合调控肿瘤细胞的机制。结果:中药联合CIK细胞能更好地提高对肿瘤细胞的杀伤作用,但其具体机制的研究只针对了某个或者多个信号分子。结论:中药联合CIK细胞治疗肿瘤,可能通过NKG2D配体-STAT3介导的机制,抑制了肺癌细胞免疫逃避,增强了CIK细胞的杀伤活性。
Objective : To investigate the mechanism of Chinese herbal medicine combined with cytokine induced killer (CIK) cells in the regulation of tumor cells, and to provide a way for the research on the mechanism of treating cancer by Chinese medicine com- bined with CIK cells. Methods:Databates on China journal full text database (CNKI), Wanfang digital periodical full text data- base, pudmed literature database, respectively find Chinese medicine and regulation of CIK cells tumor cell mechanism, and find and explore the main mechanism of combined regulation of tumor cell. Results : Chinese medicine combined with CIK cells can better im- prove the killing effect of tumor cells, but the specific mechanism of the study is aimed at a certain or more signal molecules. Conchlsion:Chinese herbal medicine combined with CIK cells in the treatment of tumor, may be through the NKG2D ligand - STAT3 mediated mechanism, inhibit the immune evasion of lung cancer cells, and enhance the CIK cell killing activity.
出处
《亚太传统医药》
2016年第3期53-55,共3页
Asia-Pacific Traditional Medicine