精液指标与体外受精助孕后孕早期自发性流产的相关分析

Analysis of correlation between sperm indicators and early spontaneous abortion after in vitro fertilization

目的探讨男方精液指标与体外受精助孕患者孕早期自发性流产的相关性。方法回顾性分析该院接受体外受精助孕的夫妻251对,根据女方是否发生早期自发性流产分为研究组(98对)及对照组(153对),分析2组中男方的精子DNA碎片率、精子核蛋白不成熟率、正常形态精子百分率等指标。结果研究组男方的精子DNA碎片率、正常形态精子百分率、精子浓度、精子活力、前向精子活力等与对照组比较,差异无统计学意义(P>0.05);研究组男方的精子核蛋白不成熟率大于对照组,差异有统计学意义(P<0.05);精子核蛋白不成熟率与早期自发性流产呈弱正相关(P<0.05)。结论精子成熟障碍与孕早期自发性流产相关,精子核蛋白不成熟率可用于评估体外受精助孕者孕早期自发性流产风险。

Objective To explore the correlation hetween the sperm indicators and early spontaneous abortion after in vitro fertilization（IVF）. Methods 251 couples receiving IVF,were retrospectively analyzed and divided into the research group （98 couples） and control group （153 couples） according to whether spontaneous abortion occurring. The male＇s indicators of sperm DNA frag- mentation index （DFI）, sperm nucleopr0tein immaturity rate, percentage of normally morphologic sperms, etc. in the two groups were analyzed. Results DFI, percentage of normally morphologic sperms, sperm concentration,motility and forward motile sperm had no statistical differences between the research group and the control group（P〉0.05） ;while the sperm nucleoprotein immaturity rate of the research group was significantly higher than that of control group, the difference was statistically significant （P〈0, 05）;the sperm nucleoprotein immaturity rate had weak correlation with spontaneous abortion in early pregnancy （P〈0. 05）. Conclusion The sperm nucleoprotein dysmaturity is correlated with the spontaneous abortion in early pregnancy. The sperm nucleoprotein immaturity rate could be used to evaluate the risk of spontaneous abortion in early pregnancy after IVF.