鼻咽癌患者放疗前后同型半胱氨酸水平检测的临床意义

Clinical significance of homocysteine level detection before and after radiotherapy in patients with nasopharynx cancer

目的探讨检测鼻咽癌患者放疗前后同型半胱氨酸水平的临床意义。方法 2013年9月至2014年9月于该院确诊的鼻咽癌患者62例纳入观察组,60例体检健康者纳入对照组。采集对照组1次静脉血,采集观察组鼻咽癌患者放疗前及放疗开始后1周、1月静脉血,并采用循环酶法检测同型半胱氨酸水平后进行比较。结果放疗前各分期鼻咽癌患者同型半胱氨酸水平比较,差异无统计学意义(F=0.15,P=0.86)。观察组患者放疗前及放疗后1周同型半胱氨酸水平均明显高于对照组,差异有统计学意义(t=-12.1,P=0.00;t=-7.32,P=0.00),放疗后1月同型半胱氨酸水平与对照组比较,差异无统计学意义(t=-1.45,P=0.15)。放疗后1周及1月鼻咽癌患者同型半胱氨酸水平明显降低,与放疗前比较,差异均有统计学意义(t=-5.22,P=0.00;t=-13.56,P=0.00)。结论鼻咽癌患者体内同型半胱氨酸水平明显升高,随着放疗的进行,同型半胱氨酸水平呈下降趋势,提示其对鼻咽癌的诊断及治疗具有一定的指导价值,但不同分期鼻咽癌患者同型半胱氨酸水平无明显差异。

Objective To investigate the clinical significance of detecting the homocysteine （Hcy） level by enzymatic cycling assay before and after radiotherapy in nasopharynx cancer. Methods 62 cases of definitely diagnosed nasopharynx cancer in our hospital from September 2013 to September 2014 were included into the observation group and 60 individuals undergoing the physical examination were enrolled as the control group. The venous blood was collected once in the control group and was collected before radiotherapy and at 1 week, 1 month after the radiotherapy beginning in the observation group. The enzymatic cycling assay was used to test the Hcy level. Then the detection results were compared between the two groups. Results The Hcy level had no statistically significantly difference among different stages of nasopharynx cancer before radiotherapy（F= 0.15, P=0.86）. The H cy level before radiotherapy and at 1 week after radiotherapy in the observation group were significantly higher than that in the control group,the difference was statistically significant（t=-12.1 ,P〈0.05;t=-7.32,P=0.00）. The Hey level at 1 month after radio therapy in the observation group had no statistical difference compared with that in the control group（t=-1.45, P= 0.15）. The Hcy level at 1 week and 1 month after radiotherapy in the observation group was significantly reduced, which showed statistical difference compared with before radiotherapy （t= -5.22, P= 0.00;t= - 13.56, P = 0.00）. Conclusion The Hcy level in the patients with nasopharynx cancer is significantly increased, whereas with the conducting radiotherapy, which shows the decreasing trend, indicating that the Hey level has certain guidance value for the diagnosis and treatment of nasopharynx cancer, but the Hey level has no obvious difference among different stages of nasopharynx cancer.