对南通地区0-3岁婴幼儿25-羟维生素D检测结果的分析

Analysis of measurement results of 25-hydroxy vitamin D among 0-3 years old infants in Nantong area

目的了解南通地区0-3岁婴幼儿25-羟维生素D[25-（OH）D]的水平,为科学合理指导婴幼儿维生素D的补充提供理论依据。方法对2014年1-6月来该院儿童保健门诊进行常规检查的3 689例婴幼儿进行指尖末梢血25-（OH）D水平检测,并比较不同月龄及不同季度婴幼儿的25-（OH）D水平及缺乏率等。结果3 689例参与检测的婴幼儿25-（OH）D水平为（67.45±35.01）nmol/L,缺乏率为39.9%,不足率为28.9%,充足率为31.2%,缺乏、不足率合计为68.8%。0-〈2月婴幼儿25-（OH）D水平最高,2-〈6月其次,6-〈12、12-≤36月组依次降低,不同月龄婴幼儿25-（OH）D水平比较,差异有统计学意义（P〈0.05）;男婴和女婴25-（OH）D水平差异无统计学意义（P〉0.05）。0-〈2、2-〈6月两个月龄组婴幼儿在第一季度与第二季度的缺乏、不足率上比较,差异均有统计学意义（χ^274.477,P=0.000;χ^229.211,P=0.000）。结论南通地区0-3岁婴幼儿25-（OH）D缺乏、不足率较高,尤其是6月龄以上婴幼儿。

Objective To understand the levels of 25 hydroxy vitamin D [25-（OH）D] in 0-3 years old infants in Nantong area to provide the theoretical basis for the scientific and rational guidance for infantsr vitamin D supplement. Methods The level of fin- gertip peripheral blood 25-（OH）D was detected in 3 689 infants and young children undergoing the conventional health examination in the child health care clinic of our hospital from January to June 2014. The 25-（OH）D levels and deficiency rate were compared a- mong different months old and different months. Results The mean level of serum 25-（OH）D in 3 689 detected infants and young children was （67.45±35.01）nmol/L,the deficiency rate was 39.9% ,the insufficient rate was 28.9% and the sufficient rate was 31.2%,the deficiency rate and insufficient rate were added up to 68.8% ;0-〈2 months old infants had the highest 25-（OH）D, followed by 2-〈6 months old infants,which in 6-〈12,12-≤36 months old groups was gradually decreased in turn,the 25 （OH）D level had statistical differences among different months old infants and young children（P〈0.05） ;the 25-（OH）D level had no statistical differences between male and female infants（P〉0.05）. The deficiency rate and insufficient rate of 25-（OH）D in 0-〈2 months old infants and 2-〈6 months old infants had the statistical difference between the first quarter and the second quarter （χ^22=74.477,P=0.000;χ^2=29. 211,P=0. 000）. Conclusion The deficiency rate and insufficient rate of 25-（OH）Din0-3 years old infants and young children are higher in Nantong area,especially in infants and young children over 6 months old.