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对氧磷酶1基因多态性与疾病遗传易感性的研究进展 被引量:3

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摘要 对氧磷酶(PON)为一种能起催化水解磷酸酯键的芳香酯酶,发挥抗氧化应激的重要作用,PON1是PON超家族成员之一,PON1广泛分布在哺乳动物肝、肾、血、脾、脑等组织中,其活性在人群中的分布相差非常大。本文就PON1的结构、功能、基因多态性与疾病易感性的研究进展综述如下。1 PON1的结构与功能1.1 PON1的结构PON相对分子质量为44×103,等电点(PI)为5.1,是一种主要在动物肝脏内合成并分泌到血液中的钙离子依赖性磷酸酯酶,有两个特殊的Ca^2+结合位点,无论体内或体外必须依赖钙离子的存在而保持酶活性。
作者 王晓刚
出处 《国际检验医学杂志》 CAS 2016年第3期369-371,共3页 International Journal of Laboratory Medicine
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参考文献36

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二级参考文献52

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