深圳某区7岁以下儿童乙肝疫苗免疫成功率现状分析

Analysis of success rate of hepatitis B vaccination for children under age of 7 in some district of Shenzhen

目的：旨在对深圳某区7岁以下儿童接种乙肝疫苗后免疫成功率的现状做分析与评价，以期能够提高儿童乙肝疫苗免疫成功率，避免接种过乙肝疫苗的儿童感染乙肝，从而降低乙肝患病率。方法对2012年8月至2015年7月在本院按照“4‐2‐1”做儿童健康体检的1903名儿童按＜1岁、1～2岁、2～3岁、3～4岁、4～5岁、5～6岁、6～7岁进行分组，采集其采用手指末梢全血检测（乳胶法）测所测乙肝表面抗体（HBsAb）阳性水平数据进行分析。结果深圳市某区儿童 HBsAb 阳性率为45．19％，其中＜1岁 HBsAb 阳性率较高为62．39％，4～5岁 HB‐sAb 阳性率最低为33．33％。结论深圳市某区7岁以下儿童 HBsAb 阳性率低于2006年全国乙肝血清流行病学调查结果，儿童抵抗乙肝病毒能力相对较弱，需要进一步探讨其存在原因。

Objective To improve the success rate of hepatitis B vaccination and prevent children who received hepatitis B vaccination from infection of hepatitis B virus ,thereby reducing hepatitis B prevalence ,through hepatitis B vaccine analysis and evaluation of children under age of 7 who received hepatitis B vaccination in a district of Shenz‐hen .Methods Total 1903 children who made health examination per the hospital′s procedure ＂4‐2‐1＂ in period of August 2012 to July 2015 were studied ,with collection of finger tip whole blood detection （latex method） to measure hepatitis B surface antibody （HBsAb） ,to analyze HBsAb positive level by age classification of 〈 1 year old ,1 to 2 yeard old ,2 to 3 years old ,3 to 4 years old ,4 to 5 years old ,5 to 6 years old and 6 to 7 years old .Results Child HB‐sAb positive rate was 45 .19% in that district of Shenzhen ,of which HBsAb positive rate was higher for those chil‐dren under 1 year old ,and it was 62 .39% .The lowest HBsAb rate was 33 .33% for children′s age between 4 and 5 years old .Conclusion In that district of Shenzhen ,children under 7 years old whose HBsAb positive rate was less than the average data of 2006 national hepatitis B serum epidemiology survey ,children′s resistance to HBV was rela‐tively weak ,and need further investigation to find out reasons .