2′-脱氧-7-去氮腺苷的合成研究

Synthesis of 2'-Deoxytubercidin

本文合成抗肿瘤化合物2′-脱氧-7-去氮腺苷。合成方法是以间氰基乙酸乙酯、2-溴-1-二乙氧基乙烷为原料合成7-去氮嘌呤碱基,再通过和1-氯-2′-脱氧核糖进行SN2取代,氨水脱保护得到,中间体及目标产物的结构通过1H NMR、13C NMR进行了表征。

The synthesis of 2’-deoxidation Tubercidin was studied in this paper. 6-Chloro-7H-pyrrolo-[2, 3-d]pyrimidine was successfully obtained by the reaction of ethyl cyanacetate and bromoacetaldehyde diethylacetal. And this was followed by SN2 substitution with a 1-chloro-2′-deoxyribose. The protecting group was then removed by treating with saturated ammonia. The structures of intermediate product and TM were confirmed by 1H NMR, 13 C NMR.