T细胞分化蛋白2在原发性肝细胞癌的表达及临床意义

Expression and Clinical Significance of MAL2 in Patients with Primary Hepatocellular Carcinoma

目的探讨T细胞分化蛋白2(MAL2)在原发性肝细胞癌(PHC)组织中的表达情况及临床意义。方法采用免疫组化染色检测并比较226例PHC患者肿瘤组织和86例正常肝组织中MAL2蛋白的表达情况。采用单因素及多因素分析影响MAL2蛋白在PHC组织中表达的危险因素,并比较不同MAL2表达水平患者的生存情况。结果随访209例。MAL2蛋白在PHC组织中的表达总阳性率显著高于正常肝组织(P<0.05)。血管侵犯、淋巴结转移和较高的TNM分期是引起MAL2蛋白表达水平增高的危险因素(P<0.05)。MAL2蛋白阳性表达患者术后生存率显著低于阴性表达患者(P<0.05)。结论 MAL2蛋白在肝癌组织中呈过表达,且与肿瘤转移及术后生存率密切相关。

Objective To determine the expression and clinical significance of T-cell differentiation protein2 （MAL2） in tissues of patients with primary hepatocellular carcinoma （PHC）. Methods Expressions of MAL2 protein in tumor tissues of 226 PHC patients and 86 cases of normal liver tissues were examined using immunohistochemistry stai- ning method. The risk factors of affecting MAL2 expression in PHC tissues were analyzed using univariate and muhivari- ate statistical analysis, and the survival rate was compared between the different expressions of MAL2 protein in PHC pa- tients. Results A total of 209 patients were followed up. The total positive rate of MAL2 expression in PHC tissues was significantly higher than that in normal liver tissues （P 〈 0.05）. The vascular invasion, lymph node metastasis and ad- vanced tumour node metastases （TNM） stage were the independent risk factors of inducing the increased expression of MAL2 protein in PHC patients （P 〈 0. 05 ）. The postoperative survival rate of patients with positive MAL2 expression was significantly lower than that of patients with negative MAL2 expression （P 〈 0. 05）. Conclusion MAL2 protein has over-expression trend in liver tumor tissues, and it is closely related to tumor metastasis and postoperative survival rate.