高尔基体糖蛋白-73在非小细胞肺癌中的表达及意义

Expression and Significance of Golgi Protein 73 in Non- small- cell Lung Cancer

目的研究非小细胞肺癌（non—small—cell lung cancer，NSCLC）和正常肺组织中高尔基体糖蛋白-73（Golgipro—tein73，GP73）的表达差异，探讨GP73表达与NSCLC发生、发展及其预后的相关性。方法免疫组织化学法检测90例NSCLC组织和19例肺正常组织GP73的表达，结合临床病理因素分析其与NSCLC预后的相关性。ROC曲线分析GP73用于肺腺癌和鳞癌鉴别诊断的价值。结果NSCLC中GP73表达较正常肺组织高，两者比较差异有统计学意义（P〈0．05），GP73表达与组织学类型及临床病理分期显著相关，而与NSCLC肿瘤分化程度、性别、年龄及术后生存期不相关。ROC曲线下面积为O．710（95％可信区间为0．590～0．831，P〈0．05）。结论GP73在NSCLC组织中高表达，且与病理类型及I临床分期显著相关，GP73对肺腺癌和鳞癌的鉴别诊断具有潜在价值。

Objective To investigate the expression of Golgi protein - 73 （GP73） in non - small - cell lung cancer （NSCLC） and normal lung tissues, and evaluate the significance of GP73 in the diagnosis and prognosis of NSCLC. Methods The expression of GP73 was detected by immunohistochemistry in 90 tissues of NSCLC and 19 tissues of normal lung. The correlation of GP73 and NSCLC prognosis was analyzed and receiver operating characteristic （ROC） curve analysis was used for the differentiation of lung adenocarcinoma and squamous cell cancer. Results GP73 expressed in NSCLC primary lesions was obviously higher than that in normal lung tissues （P 〈 0. 05 ）. GP73 expression was significantly associated with histopathology type （ P 〈 0.01 ） and clinical stage （ P 〈 0.05 ） , nevertheless, it was not associated with tumor differentiation, age, gender and survival time of NSCLC patients. The area under ROC curve for lesion GP73 was 0. 710 （95% CI： 0. 590 - 0. 831, P 〈0.05）. Conclusion GP73 in NSCLC primary lesions is high expression, mainly in the glandular epithelium cell of lung adenocarcinoma, and correlated with clinical stage. ROC curve analysis revealed that GP73 is a potential biomarker to discriminate adenocarcinoma from squamous cell carcinoma in NSCLC patients.