摘要
目的:探讨KAI1/CD82蛋白在贲门癌组织中的表达及其与贲门癌临床病理特征的关系。方法:应用免疫组织化学法检测46例贲门癌组织和相应标本的46例非肿瘤性粘膜组织KAI1/CD82蛋白的表达。结果:KAI1/CD82蛋白在癌组织中表达较非肿瘤性粘膜明显增强(P<0.05)。KAI1/CD82蛋白表达与贲门癌患者的年龄显著性相关(P<0.05),与其它临床病理特征没有显著性关系(P>0.05)。结论:KAI1/CD82蛋白的表达可能参与了贲门癌的发生发展。检测KAI1/CD82表达有助于进一步了解贲门癌发生发展的机制。
Objective： To investigate the expression of KAI1 / CD82 in gastric cardia cancer tissue and its correlation with clinical pathological parameter. Method： KAI1 / CD82 expression level was detected in 46 cases of gastric cardia cancer tissue and the corresponding non-tumor gastric tissues by the immunohistochemistry. Result： The expression level of KAI1 / CD82 was significantly higher in gastric cardia cancer tissue compared with non-tumor gastric tissues（ P〈 0. 05）. The expression of KAI1 / CD82 had no relationship with histological grade.The expression of KAI1 / CD82 correlated with patient age（ P〈 0.05） and had no relationship with other pathological parameters. Conclusion： The expression of KAI1 / CD82 may participate in the development of gastric cardia cancer. Detecting KAI1 / CD82 will help to learn the mechanism of gastric cardia cancer development.
出处
《河北医学》
CAS
2016年第1期4-7,共4页
Hebei Medicine
基金
广东省医学科研基金项目资助
(编号:B201511)
关键词
贲门癌
免疫组织化学法
非肿瘤性粘膜
Gastric cardia cancer
Immunohistochemistry
Non-tumor gastric tissue
