屈螺酮炔雌醇复合片治疗多囊卵巢综合征临床应用研究

The Effect of the Composite Tablet of Droopiness Ethylene Lestrade in Poly Cystic Ovary Syndrome

目的:探讨屈螺酮炔雌醇复合片治疗多囊卵巢综合征的临床疗效和副作用。方法:对2011年5月至2013年5月我院收治的39例多囊卵巢综合征患者的临床资料进行回顾性分析,根据治疗方案分为优思明组(屈螺酮炔雌醇)和达英-35组(炔雌醇环丙孕酮)。比较两组患者治疗前后血脂、糖代谢、性激素等相关指标,了解两种药物在治疗多囊卵巢综合症中的效果和副作用。结果:达英-35治疗前后T差为(-0.27±0.15),优思明组为(-0.269±0.074);LH差达英-35为(-8.66±5.85),优思明为(-8.786±4.82);FSH差达英为(-1.03±1.93),优思明为(-1.555±0.629),LH、T、FSH三项指标两组间差异P>0.05,两种药物在治疗PCOS的高雄激素血症等方面无明显优势,体重、胰岛素、血糖等指标差异具有统计学意义(P<0.05)。结论:屈螺酮炔雌醇复合片治疗多囊卵巢综合征的临床疗效明显,副作用与一般避孕药的作用基本一样。

Objective： To investigate clinical efficacy and side effects of droopiness ethylene lestrade tablets in the treatment of polycystic ovary syndrome. Method： The clinical data of 39 cases of patients with poly cystic ovary syndrome in May 2011 to May 2013 in our hospital were retrospectively analyzed,according to the treatment program,they were divided into Jasmine group and Diane-35 group. Two groups of patients were examined before and after treatment,lipids,glucose metabolism,hormones and other related indicators were compared,the effects and side effects of the two drugs in the treatment of poly cystic ovary syndrome were studied. Result： The difference of T before and after treatment in Diane-35 was（-0. 27 ± 0. 15）,while that in Jasmine group was（-0.269 ± 0.074）; The difference of LH in Diane-35 was（-8.66 ± 5.85）,while that in Jasmine was（-8. 786 ± 4. 82）; FSH difference in Diane-35 was（-1. 03 ± 1. 93）,while that in Jasmine was（-1.555 ± 0.629）,the difference of LH,T,FSH three indicators between the two groups P〈0.05,in the treatment of PCOS hyperthyroidism,etc. The two drugs had no obvious advantage,the differences of indicators as weight,insulin,blood sugar were statistically significant（ P〈0. 05）. Conclusion： The composite tablet of dnroopiness ethylene lestrade in the treatment of poly cystic ovary syndrome has obvious clinical efficacy,and the the side effects ane the same withe grneral contraceptives.