右美托咪定持续输注对老年患者血流动力学麻醉药用量及术后苏醒的影响

Influences of Dexmedetomidine Continuous Infusion on Hemodynamics Anesthetic Dosage and Postoperative Recovery of Elderly Patients

目的:探讨老年患者血流动力学、麻醉药用量及术后苏醒受到右美托咪定持续输注的影响。方法:随机选取2012年8月至2015年8月我院收治的70例老年患者,依据随机数字表法将患者分为两组,即研究组(n=35)和对照组(n=35)。给予研究组患者右美托咪定持续输注,给予对照组患者生理盐水泵入。结果:输注8min、10min后研究组患者的血压、心率、BIS值均显著低于对照组(P<0.05),输注5min后的血压显著高于对照组(P<0.05);插管后、拔管时研究组患者的血压、心率均显著低于对照组(P<0.05);研究组患者的丙泊酚、瑞芬太尼用量均显著少于对照组(P<0.05),BIS70、BIS80、睁眼时间均显著长于对照组(P<0.05)。结论:右美托咪定持续输注能够对老年患者血流动力学的稳定进行有效的维持,有效减少麻醉药用量,但会延长术后苏醒时间。

Objective： To investigate the influences of dexmedetomidine continuous infusion on hemodynamics,anesthetic dosage and postoperative recovery of elderly patients. Method： 70 cases of elderly patients in our hospital from August 2012 to August 2015 were randomly selected and divided into two groups according to the random number table,the study group（ n = 35） and control group（ n = 35）. The study group were given dexmedetomidine continuous infusion,while the control group were given saline pumped.Result： The blood pressure,heart rate,BIS values after infusion for 8min,10 min of the study group were significantly lower（ P〈0. 05）,the blood pressure after infusion for 5min was significantly higher（ P〈0.05）; the blood pressure and heart rate after intubation and extubation were significantly lower（ P〈0.05）;the propofol and remifentanil use were significantly less（ P〈0.05）,the BIS70,BIS80 eyes open time were significantly longer than those of the control group（ P〈0.05）. Conclusion： Dexmedetomidine continuous infusion can maintain hemodynamics stable effectively,reduce amount of anesthetic,but will extend postoperative recovery time of elderly patients.