联合全血超敏C-反应蛋白和白细胞计数在儿童呼吸道感染中的应用价值

Application Value of hs-CRP Combined with WBC in Children with Respiratory Tract Infection

目的:探讨全血超敏C-反应蛋白(hypersensitive C-reactive protein,hs-CRP)联合白细胞计数(White blood cell count,WBC)在儿童呼吸道感染中的应用价值。方法:临床纳入73例呼吸道细菌性感染患儿与47例呼吸道病毒性感染患儿。此外,研究纳入50例健康的儿童作为研究对照。分别检查上述各组患儿全血hs-CRP与WBC水平,并进行分析。结果:细菌性感染组hs-CRP、WBC水平分别为(18.25±4.32)mg/L、(13.55±1.05)×109L-1,病毒性感染组hs-CRP、WBC水平分别为(4.05±2.91)mg/L、(7.97±2.11)×109L-1,健康组hs-CRP、WBC水平分别为(2.97±0.75)mg/L、(7.05±1.95)×109L-1,差异有显著性(P<0.05);治疗后,细菌性感染组hs-CRP、WBC水平较治疗前明显下降,差异有显著性(P<0.05);hs-CRP≥8mg/L时,hs-CRP诊断细菌感染灵敏度、特异度、阳性预测值、阴性预测值分别为86.30%、50.68%、56.16%、83.56%;WBC≥10×109L-1时,hs-CRP诊断细菌感染灵敏度、特异度、阳性预测值、阴性预测值分别为82.19%、68.49%、65.75%、83.56%。结论:hs-CRP与WBC对诊断及鉴别儿童呼吸道感染具有较高的指导价值,其中hs-CRP在诊断细菌性感染时具有更高的灵敏度、特异度以及准确率。

Objective： To study the application value of hs-CRP combined with WBC in children with respiratory tract infection. Method： 73 children with respiratory tract bacterial infection,47 children with viral respiratory infection and 50 healthy children were selected. The levels of hs-CRP and WBC of each group were detected and analyzed. In addition,the changes of hs-CRP and WBC of bacterial infection and viral infection group before and after treatment were observed. Regarding the positive criteria of hs-CRP ≥8mg / L and WBC≥10×10^9L^-1,the sensitivity,specificity,positive predictive value and negative predictive value of bacterial infection based on hs-CRP and WBC was calculated. Result： The levels of hs-CRP and WBC of bacterial infection group were（ 18.25±4.32） mg / L and（ 13.55 ± 1.05） × 10^9L^-1; the levels of hs-CRP and WBC of viral infection group were（ 4.05±2.91） mg / L and（ 7.97±2.11） ×10^9L^-1,while the levels of healthy group were（ 2.97±0.75） mg / L and（ 7.05±1.95） ×10^9L^-1（ P0.05）; after treatment,the levels of hs-CRP and WBC of bacterial infection group were significantly lower than before（ P〈0.05）; when hs-CRP≥8mg /L,the sensitivity,specificity,positive predictive value and negative predictive value of bacterial infection based on hs-CRP was 86.30%,50.68%,56.16% and 83.56%; when WBC≥10 × 109L-1,the sensitivity,specificity,positive predictive value and negative predictive value of bacterial infection based on WBC was82.19%,68.49%,65.75% and 83.56%.Conclusion： hs-CRP and WBC has a higher guiding value in the diagnosis and identification of respiratory tract infection. During the diagnosis process of bacterial infection,hs-CRP has a higher sensitivity,specificity and accuracy.