巨细胞性胶质母细胞瘤一例

Clinicopathologic study of giant cell glioblastoma

目的探讨巨细胞胶质母细胞瘤(GCG)的临床病理特征、诊断及鉴别诊断。方法对1例巨细胞胶质母细胞瘤进行临床病理分析及免疫组化研究。结果巨细胞胶质母细胞瘤组织学特征为瘤细胞形态多样,以巨怪形多核巨细胞为主,核分裂像和坏死多见,网状纤维沿血管周围分布。瘤细胞弥漫表达Vim、S-100及GFAP灶性阳性,Ki-67约为20%。结论 GCG是一种罕见的具有特殊临床病理特征的及预后差的中枢神经系统肿瘤。病理组织学上需与多形性黄色瘤型星形细胞瘤、胶质肉瘤等鉴别。

Objective To explore the clinicopathological characteristics of giant cell glioblastoma and investigate its diagnosis, differential diagnosis. Methods Clinicopathologieal examination and immunohistochemical findings were analyzed in one case of giant cell glioblastoma, and the recently related literature was reviewed.Results Histologically, the tumor cells with pleomorphism, gave priority to with Johnson tumor giant cells, nuclear fission and necrosis, reticular fiber distribution was around the blood vessels . Immunohistochemistry revealed positive results for Vim, S-100, GFAP.The labeling index of Ki-67 was20%. Conclusion Giant cell glioblastoma is a rare central nervous system tumour with special clinical pathological features and prognosis. On the pathologic histology GCG should be ideutified with pleomorphic xanthoma astrocytoma and colloid sarcoma identification, etc.