血液透析合并慢性乙型肝炎患者血清β2-微球蛋白水平及其影响因素

Level of serum beta2-microglobulin and its influencing factors in hemodialysis patients with chronic hepatitis B

目的观察血液透析合并慢性乙型肝炎(简称慢性乙肝)患者血清β2-微球蛋白(β2-MG)水平,并探讨血清β2-MG的影响因素。方法按照"慢性乙型肝炎防治指南(2010年版)"筛选行血液透析治疗的慢性乙肝患者,30例纳入研究。选择30例乙肝病毒(HBV)阴性的血液透析患者作为对照组;用t检验比较两组实验室指标,用多元线性回归分析法分析影响血清β2-MG的因素。结果 HBV阳性组血清β2-MG水平为(65.64±10.18)μg/ml,较HBV阴性组(44.90±12.81)μg/ml显著升高(P<0.010)。多元线性回归分析显示,血清β2-MG水平与血清清蛋白呈负相关(B=-0.001,P=0.015),与HBV感染、透析龄及谷丙转氨酶呈正相关(B=14.127,P=0.000;B=0.421,P=0.001;B=0.077,P=0.032)。结论血液透析合并慢性乙肝患者血清β2-MG水平较HBV阴性的血液透析患者显著升高,且与血清清蛋白、谷丙转氨酶、HBV感染及透析龄有关。

Objective To observe the level of serum beta2-microglobulin（β2-MG）in hemodialysis patients with chronic hepatitis B,and to discuss its influencing factors.Methods Referring to Guidelines for Chronic Hepatitis B in China（version 2010）,30 hemodialysis patients with chronic hepatitis B were included in this study.And 30 hemodialysis patients without hepatitis B virus（HBV）were selected as controls.Blood laboratory indexes were compared by t test.Factors influnecing serum β2-MG were analyzed with multiple linear regression analysis.Results The level of serum β2-MG in the HBV-positive group was（65.64 ± 10.18）μg/ml which was significantly higher than（44.90 ± 12.81）μg/ml in the HBV-negative group（P〈0.01）.Multiple linear regression analyses showed that the level of serum β2-MG was negatively correlated to serum albumin（ALB）（B =-0.001,P = 0.015）,and positively correlated to HBV infection,duration of dialysis and alanine aminotransferase（ALT）（B = 14.127,0.421 and 0.077;P = 0.000,0.001 and 0.032 respectively）.Conclusions The level of serum β2-MG in hemodialysis patients with chronic hepatitis B is significantly high when compared with hemodialysis patients without HBV infection.And serum β2-MG is associated with serum ALB and ALT,HBV infection and duration of dialysis.