摘要
以γ-环糊精(γ-CD)为主体分子,研究γ-CD对槲皮素和DL-扁桃酸的包结。采用液-液法获得了γ-CD-槲皮素、γ-CD-扁桃酸两个包结物,由FT-IR、1H NMR表征。结果表明,γ-CD与槲皮素、扁桃酸包结比分别为1:1和2:3。25℃下,γ-CD对槲皮素的相溶解度研究证实γ-CD对槲皮素包结比为1:1,γ-CD对槲皮素的包结常数为574 L/mol;槲皮素在γ-CD中的溶解度提高到1.33 mg/m L。γ-CD-扁桃酸包结物的比旋光度研究表明γ-CD对左、右旋体扁桃酸的包结没有选择性。
The paper reported the inclusion of γ-cyclodextrin(γ-CD)to sophretin and DL -man-delic acid using γ-CD as a host molecule.Two complexes of γ-CD -sophretin and γ-CD -mandelic acid were successfully synthesized via liquid -liquid inclusion reaction,and their structures were character-ized by IR and 1H NMR.Results from 1H NMR showed that molar ratios on γ-CD -sophretin and γ-CD -mandelic acid (CD∶host)were 1∶1 and 2∶3,respectively.At 25 ℃,results from the study on phase solubility of sophretin in γ-CD confirmed the molar ratio of γ-CD to sophretin to be 1∶1,and the inclusion equilibrium constant of γ-CD to sophretin 574 L·moL -1 ;then,the solubility of sophretin in γ-CD reached 1.33mg·mL -1 .Study on specific rotation of γ-CD -mandelic acid exhibited that there was no enantioselective when γ-CD formed complex with D or L -mandelic acid.
出处
《云南化工》
CAS
2016年第1期19-23,共5页
Yunnan Chemical Technology
